Melatonin Versus Chloral Hydrate for Sleep Electroencephalography Recording in Children: A Comparative Study Using Bispectral Index Monitoring Scores and Electroencephalographic Sleep Stages

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dc.authorscopusid36571118200
dc.authorscopusid57189047650
dc.authorscopusid25222311100
dc.authorscopusid57205024338
dc.authorscopusid6507501701
dc.authorscopusid55968773100
dc.contributor.authorYilmaz, Sanem
dc.contributor.authorSimsek, Erdem
dc.contributor.authorTekin, Hande Gazeteci
dc.contributor.authorAktan, Gul
dc.contributor.authorGokben, Sarenur
dc.contributor.authorTekgul, Hasan
dc.date.accessioned2023-01-12T20:01:02Z
dc.date.available2023-01-12T20:01:02Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: To compare the effects of chloral hydrate and melatonin on sleep EEG recordings in children by using standard EEG sleep stages and the bispectral index scores (BIS). Methods: A total of 86 children were randomly assigned to two groups: (1) melatonin group (n = 43) and (2) chloral hydrate group (n = 43). BIS monitoring scores and sleep EEGs were recorded simultaneously. The effect of two drugs on sleep EEG recording was evaluated with sleep stages of EEG and BIS. Results: There was no statistically significant difference between the groups with regard to time to sleep onset and the need for a second drug (P = 0.432; P = 1.000). Eight patients (18.6%) in chloral hydrate group reported side effects while there were no reported side effects in the melatonin group (P = 0.006). Mean BIS values during EEG recordings were similar in both groups (59.72 +/- 18.69 minutes and 66.17 +/- 18.44 minutes, respectively, P = 1.000). The average time to achieve N2 sleep was 32.38 minutes in the chloral hydrate group and 43.25 minutes in the melatonin group (P < 0.001). Both time spent in wakefulness and N1 sleep were found to be significantly higher in the melatonin group (P < 0.001 and P = 0.005). BIS scores higher than 75 were found to be suggestive for wakefulness; 75 to 66 for N1, 65 to 46 for N2, and values lower than 46 were found to be indicative for N3 sleep with a good strength of agreement in weighted Kappa analysis (95% confidence interval; weighted Kappa = 0.67). Conclusions: Melatonin is reliable and at least as effective as chloral hydrate for sleep EEG acquisition in children.en_US
dc.identifier.doi10.1097/WNP.0000000000000829
dc.identifier.endpage630en_US
dc.identifier.issn0736-0258
dc.identifier.issn1537-1603
dc.identifier.issue7en_US
dc.identifier.pmid33606431en_US
dc.identifier.scopus2-s2.0-85141889848en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.1097/WNP.0000000000000829
dc.identifier.urihttps://hdl.handle.net/11454/77422
dc.identifier.volume39en_US
dc.identifier.wosWOS:000878746500016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Clinical Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBispectral indexen_US
dc.subjectChildrenen_US
dc.subjectChloral hydrateen_US
dc.subjectMelatoninen_US
dc.subjectSleep EEGen_US
dc.subjectSedationen_US
dc.subjectDeprivationen_US
dc.subjectHydroxyzineen_US
dc.subjectEegen_US
dc.subjectDepthen_US
dc.titleMelatonin Versus Chloral Hydrate for Sleep Electroencephalography Recording in Children: A Comparative Study Using Bispectral Index Monitoring Scores and Electroencephalographic Sleep Stagesen_US
dc.typeArticleen_US

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