Melatonin Versus Chloral Hydrate for Sleep Electroencephalography Recording in Children: A Comparative Study Using Bispectral Index Monitoring Scores and Electroencephalographic Sleep Stages
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To compare the effects of chloral hydrate and melatonin on sleep EEG recordings in children by using standard EEG sleep stages and the bispectral index scores (BIS). Methods: A total of 86 children were randomly assigned to two groups: (1) melatonin group (n = 43) and (2) chloral hydrate group (n = 43). BIS monitoring scores and sleep EEGs were recorded simultaneously. The effect of two drugs on sleep EEG recording was evaluated with sleep stages of EEG and BIS. Results: There was no statistically significant difference between the groups with regard to time to sleep onset and the need for a second drug (P = 0.432; P = 1.000). Eight patients (18.6%) in chloral hydrate group reported side effects while there were no reported side effects in the melatonin group (P = 0.006). Mean BIS values during EEG recordings were similar in both groups (59.72 +/- 18.69 minutes and 66.17 +/- 18.44 minutes, respectively, P = 1.000). The average time to achieve N2 sleep was 32.38 minutes in the chloral hydrate group and 43.25 minutes in the melatonin group (P < 0.001). Both time spent in wakefulness and N1 sleep were found to be significantly higher in the melatonin group (P < 0.001 and P = 0.005). BIS scores higher than 75 were found to be suggestive for wakefulness; 75 to 66 for N1, 65 to 46 for N2, and values lower than 46 were found to be indicative for N3 sleep with a good strength of agreement in weighted Kappa analysis (95% confidence interval; weighted Kappa = 0.67). Conclusions: Melatonin is reliable and at least as effective as chloral hydrate for sleep EEG acquisition in children.
Açıklama
Anahtar Kelimeler
Bispectral index, Children, Chloral hydrate, Melatonin, Sleep EEG, Sedation, Deprivation, Hydroxyzine, Eeg, Depth
Kaynak
Journal of Clinical Neurophysiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
39
Sayı
7
