Biological investigation of I-131-labeled new water soluble Ru(II) polypyridyl complex

New [Ru(L1)(dcbpy)(NCS)(2)] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)](2), where the ligands (dcbpy = 4,4'-dicarboxy-2,2'-bipyridine, L1 = dipyrido[3,2-a:2',3'-c]phenazine-11-ylcarbonyl) -sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using I-131-labeled [Ru(L1)(dcbpy)(NCS)(2)] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen. (C) 2007 Elsevier Ltd. All rights reserved.