MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome

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dc.contributor.authorKaraca, Emin
dc.contributor.authorAykut, Ayca
dc.contributor.authorErturk, Biray
dc.contributor.authorDurmaz, Burak
dc.contributor.authorGuler, Ahmet
dc.contributor.authorBuke, Baris
dc.contributor.authorYeniel, Ahmet Ozgur
dc.contributor.authorErgenoglu, Ahmet Mete
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorOzeren, Mehmet
dc.contributor.authorKazandi, Mert
dc.contributor.authorAkercan, Fuat
dc.contributor.authorSagol, Sermet
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorCogulu, Ozgur
dc.date.accessioned2019-10-27T10:42:11Z
dc.date.available2019-10-27T10:42:11Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Down syndrome, which is the most common human chromosomal anomaly that can affect people of any race and age, can be diagnosed prenatally in most cases. Prenatal diagnosis via culture method is time-consuming; thus, genetic analysis has thus been introduced and is continually being developed for rapid prenatal diagnosis. For this reason, the effective use of microRNA profiling for the rapid analysis of prenatal amniotic fluid samples for the diagnosis of Down syndrome was investigated. Aims: To evaluate the expression levels of 14 microRNAs encoded by chromosome 21 in amniotic fluid samples and their utility for prenatal diagnosis of Down syndrome. Study Design: Case-control study. Methods: We performed invasive prenatal testing for 56 pregnant women; 23 carried fetuses with Down syndrome, and 33 carried fetuses with a normal karyotype. Advanced maternal age and increased risk for Down syndrome in the screening tests were indications for invasive prenatal testing. The age of gestation in the study and control groups ranged between 17 and 18 weeks. The expression levels of microRNA were measured by real-time polymerase chain reaction. Results: The expression levels of microRNA-125b-2, microRNA-155, and microRNA-3156 were significantly higher in the study group than in the control group. Conclusion: The presence of significantly dysregulated microRNAs may be associated with either the phenotype or the result of abnormal development. Further large-scale comparative studies conducted in a variety of conditions may bring novel insights in the field of abnormal prenatal conditions.en_US
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [F30CA213956, R01NS070715]; Ege University School of MedicineEge Universityen_US
dc.description.sponsorshipFinancial support was received from Ege University School of Medicine.en_US
dc.identifier.doi10.4274/balkanmedj.2017.0511
dc.identifier.endpage166en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue2en_US
dc.identifier.pmid29219113en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.2017.0511
dc.identifier.urihttps://hdl.handle.net/11454/30641
dc.identifier.volume35en_US
dc.identifier.wosWOS:000428204000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDown syndromeen_US
dc.subjectmicroRNAsen_US
dc.subjectamniotic fluiden_US
dc.titleMicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndromeen_US
dc.typeArticleen_US

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