Anti-inflammatory phenolic glycosides from endemic Marrubium rotundifolium Boiss.

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dc.authoridDemiroz Akbulut, Tugce/0000-0002-7606-5316
dc.contributor.authorAkbulut, Tugce Demiroz
dc.contributor.authorDemir, Serdar
dc.contributor.authorAlsakini, Karrar Ali Mohammed Hasan
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorBaykan, Sura
dc.date.accessioned2024-08-31T07:47:03Z
dc.date.available2024-08-31T07:47:03Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractMarrubium rotundifolium Boiss. is an endemic plant distributed in Aegean Region of T & uuml;rkiye. It's traditionally used in Anatolian medicine for treatment of cold and flu, dyspepsia, costiveness and intestinal spasms. However, phytochemical studies on the plant are limited. In the present study, five phenolic glycosides 4',5,6,7-tetramethoxy scutellarein (1), apigenin-7-O-(3-O-E-p-coumaroyl)-beta-d-glucopyranoside (2), tiliroside (3), 4-(beta-d-glucopyranosyloxy) benzoic acid (4), and astragalin (5) were isolated from the aerial parts of M. rotundifolium and their structures were elucidated on the basis of spectroscopic methods (1D and 2D NMR, and MALDI-TOF/MS). Moreover, anti-inflammatory activities of the isolated compounds were evaluated by measurements of interleukins (IL-1 beta, IL-6) and tumour necrosis factor-alpha (TNF-alpha) levels. Tiliroside exhibited the highest potency in all pathways. At concentrations of 3 and 6 mu g/mL, it significantly decreased the levels of pro-inflammatory cytokines IL-1 beta (192.53 and 175.54 pg/mL), IL-6 (925.52 and 946.81 pg/mL), and TNF- alpha (6465.86 and 6267.67 pg/mL). This is the first report on phenolic profile of endemic M. rotundifolium. The anti-inflammatory and antidiabetic activity potential of the plant should be investigated in further studies. {Graphical Abstract}en_US
dc.identifier.doi10.1080/14786419.2024.2379011
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid39015030en_US
dc.identifier.scopus2-s2.0-85198715219en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2379011
dc.identifier.urihttps://hdl.handle.net/11454/104295
dc.identifier.wosWOS:001271725000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectEndemicen_US
dc.subjectFlavonoiden_US
dc.subjectLamiaceaeen_US
dc.subjectMarrubium Rotundifoliumen_US
dc.subjectPhenolicen_US
dc.titleAnti-inflammatory phenolic glycosides from endemic Marrubium rotundifolium Boiss.en_US
dc.typeArticleen_US

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