Anti-inflammatory phenolic glycosides from endemic Marrubium rotundifolium Boiss.
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Marrubium rotundifolium Boiss. is an endemic plant distributed in Aegean Region of T & uuml;rkiye. It's traditionally used in Anatolian medicine for treatment of cold and flu, dyspepsia, costiveness and intestinal spasms. However, phytochemical studies on the plant are limited. In the present study, five phenolic glycosides 4',5,6,7-tetramethoxy scutellarein (1), apigenin-7-O-(3-O-E-p-coumaroyl)-beta-d-glucopyranoside (2), tiliroside (3), 4-(beta-d-glucopyranosyloxy) benzoic acid (4), and astragalin (5) were isolated from the aerial parts of M. rotundifolium and their structures were elucidated on the basis of spectroscopic methods (1D and 2D NMR, and MALDI-TOF/MS). Moreover, anti-inflammatory activities of the isolated compounds were evaluated by measurements of interleukins (IL-1 beta, IL-6) and tumour necrosis factor-alpha (TNF-alpha) levels. Tiliroside exhibited the highest potency in all pathways. At concentrations of 3 and 6 mu g/mL, it significantly decreased the levels of pro-inflammatory cytokines IL-1 beta (192.53 and 175.54 pg/mL), IL-6 (925.52 and 946.81 pg/mL), and TNF- alpha (6465.86 and 6267.67 pg/mL). This is the first report on phenolic profile of endemic M. rotundifolium. The anti-inflammatory and antidiabetic activity potential of the plant should be investigated in further studies. {Graphical Abstract}
Açıklama
Anahtar Kelimeler
Anti-Inflammatory, Endemic, Flavonoid, Lamiaceae, Marrubium Rotundifolium, Phenolic
Kaynak
Natural Product Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
