Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia

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dc.contributor.authorYilmaz Karapinar D.
dc.contributor.authorKaradaş N.
dc.contributor.authorÖnder Siviş Z.
dc.contributor.authorYazici P.
dc.contributor.authorDuyu M.
dc.contributor.authorMetin D.
dc.contributor.authorKarapinar B.
dc.contributor.authorAydinok Y.
dc.date.accessioned2019-10-26T21:21:40Z
dc.date.available2019-10-26T21:21:40Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractEmpirical antifungal therapy is most often given to patients with leukemia. However breakthrough fungal infections under antifungal therapy are not uncommon. Four children, with hematologic malignant disease developed mycotic breakthrough infections while on empirical caspofungin treatment for a median of 14 (range 11-19) days. Trichosporon asahii was detected in the blood culture of two patients and Geotrichum capitatum in the other two (one patient also had positive cerebrospinal fluid culture). Because the patients' clinical situation worsened, voriconazole was empirically added for two patients three and five days before the agent was detected. The first sterile blood culture was obtained 3-7 days of voriconazole treatment. All patients reached clear cultures but one patient died. One patient with central nervous system infection with G. capitatum had severe neurological sequelae. Very severe fungal infections can occur during empirical caspofungin therapy. Therefore, patients should be followed closely. © 2015 Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/j.bjid.2015.06.008en_US
dc.identifier.endpage552en_US
dc.identifier.issn1413-8670
dc.identifier.issue5en_US
dc.identifier.pmid26275731en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjid.2015.06.008
dc.identifier.urihttps://hdl.handle.net/11454/16895
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Editora Ltdaen_US
dc.relation.ispartofBrazilian Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectGeotrichum capitatumen_US
dc.subjectInvazive fungal infectionen_US
dc.subjectTrichosporon asahiien_US
dc.titleRare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropeniaen_US
dc.typeArticleen_US

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