Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Editora Ltda
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Empirical antifungal therapy is most often given to patients with leukemia. However breakthrough fungal infections under antifungal therapy are not uncommon. Four children, with hematologic malignant disease developed mycotic breakthrough infections while on empirical caspofungin treatment for a median of 14 (range 11-19) days. Trichosporon asahii was detected in the blood culture of two patients and Geotrichum capitatum in the other two (one patient also had positive cerebrospinal fluid culture). Because the patients' clinical situation worsened, voriconazole was empirically added for two patients three and five days before the agent was detected. The first sterile blood culture was obtained 3-7 days of voriconazole treatment. All patients reached clear cultures but one patient died. One patient with central nervous system infection with G. capitatum had severe neurological sequelae. Very severe fungal infections can occur during empirical caspofungin therapy. Therefore, patients should be followed closely. © 2015 Elsevier Editora Ltda.
Açıklama
Anahtar Kelimeler
Febrile neutropenia, Geotrichum capitatum, Invazive fungal infection, Trichosporon asahii
Kaynak
Brazilian Journal of Infectious Diseases
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
19
Sayı
5
