Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells

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dc.authoridBilge, Duygu Melek/0000-0002-5229-7972
dc.contributor.authorCetinel, Zueleyha Ozcelik
dc.contributor.authorBilge, Duygu
dc.date.accessioned2024-08-31T07:48:24Z
dc.date.available2024-08-31T07:48:24Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractMiltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various types of cancer. The most crucial feature of APLs is that they are thought to only kill cancerous cells without harming normal cells. However, the molecular mechanism of action of APLs is not completely understood. The increase in the phosphatidylserine (PS) ratio is a marker showing the stage of cancer and even metastasis. The goal of this research was to investigate the molecular effects of miltefosine at the molecular level in different PS ratios. The effects of MLT on membrane phase transition, membrane orders, and dynamics were studied using DPPC/DPPS (3:1) and DPPC/DPPS (1:1) multilayer (MLV) vesicles mimicking DPPS ratio variation, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared spectroscopy (FTIR). Our findings indicate that miltefosine is evidence at the molecular level that it is directed towards the tumor cell and that the drug's effect increases with the increase of anionic lipids in the membrane depending on the stage of cancer.en_US
dc.description.sponsorshipEge University; [FDK-2019-20901]en_US
dc.description.sponsorshipWe would like to thank Ege University Scientific Research Projects Coordination for their support of this study. (The project ID is FDK-2019-20901).en_US
dc.identifier.doi10.1007/s10863-024-10025-y
dc.identifier.endpage473en_US
dc.identifier.issn0145-479X
dc.identifier.issn1573-6881
dc.identifier.issue4en_US
dc.identifier.pmid38833041en_US
dc.identifier.scopus2-s2.0-85195219573en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1007/s10863-024-10025-y
dc.identifier.urihttps://hdl.handle.net/11454/104774
dc.identifier.volume56en_US
dc.identifier.wosWOS:001239260700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Bioenergetics and Biomembranesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectFourier Transformation Infrared Spectroscopyen_US
dc.subjectDifferential Scanning Calorimetryen_US
dc.subjectMiltefosineen_US
dc.subjectDipalmitoyl Phosphatidylserine Levelen_US
dc.subjectCanceren_US
dc.titleInvestigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cellsen_US
dc.typeArticleen_US

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