Gingival crevicular fluid interleukin-36ß (-1F8), interleukin-36? (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease

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dc.contributor.authorKurşunlu S.F.
dc.contributor.authorÖztürk V.Ö.
dc.contributor.authorHan B.
dc.contributor.authorAtmaca H.
dc.contributor.authorEmingil G.
dc.date.accessioned2019-10-27T08:21:45Z
dc.date.available2019-10-27T08:21:45Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleukin (IL)-36ß, IL-36? and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases. Materials and methods A total of 80 subjects, 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with chronic periodontitis (CP), 20 with gingivitis and 20 periodontally healthy subjects were included. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, papillary bleeding index and plaque index. GCF cytokine levels were analysed by ELISA. Results CP, gingivitis and healthy groups had similar GCF IL-36ß total amount (p > 0.008). G-AgP group had elevated IL-36ß total amount compared to CP group (p < 0.008). G-AgP group had similar GCF IL-36ß total amount to gingivitis and healthy groups (p > 0.008). GCF IL-36? and IL-33 total amounts of the study groups were similar (p > 0.05). Conclusions The present study demonstrated for the first time the presence of IL-36ß, IL-36? and IL-33 GCF levels with different periodontal diseases. High levels of IL-36-ß in the AgP group in comparison to CP group might suggest that periodontitis in the aggressive form could be related to the increase in GCF IL-36ß. © 2014 Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.archoralbio.2014.08.021en_US
dc.identifier.endpage83en_US
dc.identifier.issn0003-9969
dc.identifier.issue1en_US
dc.identifier.pmid25247780en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2014.08.021
dc.identifier.urihttps://hdl.handle.net/11454/26098
dc.identifier.volume60en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectIL-33en_US
dc.subjectIL-36ßen_US
dc.subjectIL-36?en_US
dc.subjectPeriodontal disease/pathogenesisen_US
dc.titleGingival crevicular fluid interleukin-36ß (-1F8), interleukin-36? (-1F9) and interleukin-33 (-1F11) levels in different periodontal diseaseen_US
dc.typeArticleen_US

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