Gingival crevicular fluid interleukin-36ß (-1F8), interleukin-36? (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleukin (IL)-36ß, IL-36? and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases. Materials and methods A total of 80 subjects, 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with chronic periodontitis (CP), 20 with gingivitis and 20 periodontally healthy subjects were included. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, papillary bleeding index and plaque index. GCF cytokine levels were analysed by ELISA. Results CP, gingivitis and healthy groups had similar GCF IL-36ß total amount (p > 0.008). G-AgP group had elevated IL-36ß total amount compared to CP group (p < 0.008). G-AgP group had similar GCF IL-36ß total amount to gingivitis and healthy groups (p > 0.008). GCF IL-36? and IL-33 total amounts of the study groups were similar (p > 0.05). Conclusions The present study demonstrated for the first time the presence of IL-36ß, IL-36? and IL-33 GCF levels with different periodontal diseases. High levels of IL-36-ß in the AgP group in comparison to CP group might suggest that periodontitis in the aggressive form could be related to the increase in GCF IL-36ß. © 2014 Elsevier Ltd.
Açıklama
Anahtar Kelimeler
Gingival crevicular fluid, IL-33, IL-36ß, IL-36?, Periodontal disease/pathogenesis
Kaynak
Archives of Oral Biology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
60
Sayı
1
