The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats

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dc.contributor.authorBerkan T.
dc.contributor.authorÜstünes L.
dc.contributor.authorKerry Z.
dc.contributor.authorKarol M.
dc.contributor.authorTosun M.
dc.contributor.authorYalçinkaya C.
dc.contributor.authorÖzer A.
dc.date.accessioned2019-10-27T09:02:44Z
dc.date.available2019-10-27T09:02:44Z
dc.date.issued1989
dc.departmentEge Üniversitesien_US
dc.description.abstractThe effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats was studied. Pentobarbital sleep time was not affected whereas zoxazolamine paralysis time was shortened 72% in rats, 24 h after the cigarette smoke exposure. The gb-adrenoceptor blocking effect of propranolol observed at 10 and 20 min time intervals was abolished in rats exposed to cigarette smoke 24 h after the exposure. The blood propranolol concentrations were decreased in rats pretreated with phénobarbital, 3,4-benzpyrene and ethanol as well as in cigarette smoke exposed rats. Among several factors that could influence propranolol metabolism, in this study, enzyme induction is suggested to be dominant. © 1989 Springer-Verlag.en_US
dc.identifier.doi10.1007/BF03190102en_US
dc.identifier.endpage228en_US
dc.identifier.issn0378-7966
dc.identifier.issue3en_US
dc.identifier.pmid2612519en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1007/BF03190102
dc.identifier.urihttps://hdl.handle.net/11454/28404
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Drug Metabolism and Pharmacokineticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectblood levelsen_US
dc.subjectCigarette smokeen_US
dc.subjecthemodynamicsen_US
dc.subjectpropranololen_US
dc.subjectraten_US
dc.titleThe effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in ratsen_US
dc.typeArticleen_US

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