The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats
Küçük Resim Yok
Tarih
1989
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propranolol in rats was studied. Pentobarbital sleep time was not affected whereas zoxazolamine paralysis time was shortened 72% in rats, 24 h after the cigarette smoke exposure. The gb-adrenoceptor blocking effect of propranolol observed at 10 and 20 min time intervals was abolished in rats exposed to cigarette smoke 24 h after the exposure. The blood propranolol concentrations were decreased in rats pretreated with phénobarbital, 3,4-benzpyrene and ethanol as well as in cigarette smoke exposed rats. Among several factors that could influence propranolol metabolism, in this study, enzyme induction is suggested to be dominant. © 1989 Springer-Verlag.
Açıklama
Anahtar Kelimeler
blood levels, Cigarette smoke, hemodynamics, propranolol, rat
Kaynak
European Journal of Drug Metabolism and Pharmacokinetics
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
3
