I-131 labeling of tamoxifen and biodistribution studies in rats

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dc.contributor.authorMuftuler, F. Z. Biber
dc.contributor.authorUnak, P.
dc.contributor.authorTeksoz, S.
dc.contributor.authorAcar, C.
dc.contributor.authorYolcular, S.
dc.contributor.authorYurekli, Y.
dc.date.accessioned2019-10-27T19:55:26Z
dc.date.available2019-10-27T19:55:26Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractTamoxifen [TAM ([Z]-2-[4-(1,2-diphenyl-1-di-butenyl)-phenoxy]-N,N-dimethylethanamine)] has been used as an antiestrogen drug for treatment and prevention of human breast cancer. Tamoxifen was labeled with I-131 using iodogen as an oxidizing agent. Mass spectroscopy of the cold standard showed that the labeling occurs in ortho position to the phenyl ether position of TAM as expected. Quality control, radiochemical yield and stability were established using the radioelectrophoresis method. The radiolabeled compound maintained its stability throughout working period of 24 h. Scintigraphic imaging was performed and tissue distribution was determined in Albino Wistar rats. According to biodistribution and imaging experiments the radiolabeled compound presented estrogen receptor (ER) specificity and it was uptaken by endometrium as well as breast tissue. (C) 2007 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.apradiso.2007.08.005en_US
dc.identifier.endpage187en_US
dc.identifier.issn0969-8043
dc.identifier.issue2en_US
dc.identifier.pmid17888670en_US
dc.identifier.startpage178en_US
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2007.08.005
dc.identifier.urihttps://hdl.handle.net/11454/40681
dc.identifier.volume66en_US
dc.identifier.wosWOS:000253103100011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofApplied Radiation and Isotopesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantiestrogenen_US
dc.subjectI-131en_US
dc.subjectiodogen (1,3,4,6-tetrachloro-3 alpha,6 alpha)-diphenylglycouril)en_US
dc.subjectI-131-TAMen_US
dc.titleI-131 labeling of tamoxifen and biodistribution studies in ratsen_US
dc.typeArticleen_US

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