I-131 labeling of tamoxifen and biodistribution studies in rats
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Tamoxifen [TAM ([Z]-2-[4-(1,2-diphenyl-1-di-butenyl)-phenoxy]-N,N-dimethylethanamine)] has been used as an antiestrogen drug for treatment and prevention of human breast cancer. Tamoxifen was labeled with I-131 using iodogen as an oxidizing agent. Mass spectroscopy of the cold standard showed that the labeling occurs in ortho position to the phenyl ether position of TAM as expected. Quality control, radiochemical yield and stability were established using the radioelectrophoresis method. The radiolabeled compound maintained its stability throughout working period of 24 h. Scintigraphic imaging was performed and tissue distribution was determined in Albino Wistar rats. According to biodistribution and imaging experiments the radiolabeled compound presented estrogen receptor (ER) specificity and it was uptaken by endometrium as well as breast tissue. (C) 2007 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
antiestrogen, I-131, iodogen (1,3,4,6-tetrachloro-3 alpha,6 alpha)-diphenylglycouril), I-131-TAM
Kaynak
Applied Radiation and Isotopes
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
66
Sayı
2
