Hepatitis E Infection in Solid Organ Transplant Recipients in Turkey

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dc.authoridOtlu, Baris/0000-0002-6220-0521
dc.authorscopusid57430395500
dc.authorscopusid57093607600
dc.authorscopusid6602612326
dc.authorscopusid6505967744
dc.authorscopusid6602884995
dc.authorscopusid6602362710
dc.authorscopusid36131018100
dc.contributor.authorOgut, Seval
dc.contributor.authorSayiner, Ayca Arzu
dc.contributor.authorOtlu, Baris
dc.contributor.authorBozdayi, Gulendam
dc.contributor.authorZeytinoglu, Aysin
dc.contributor.authorAksaray, Sebahat
dc.contributor.authorColak, Dilek
dc.date.accessioned2023-01-12T20:18:45Z
dc.date.available2023-01-12T20:18:45Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Hepatitis E virus is a re-emerging pathogen with an increase in human cases that can lead to chronic infection in immunosuppressed patients. Turkey is located between Asia and Europe, 2 regions with distinct epidemiological and clinical features of hepatitis E virus infection. This multicenter cross-sectional study aimed to investigate the prevalence of hepatitis E virus infection in liver and kidney transplant recipients in Turkey and to determine the role of possible transmission factors. Methods: A total of 485 plasma samples of solid organ recipients were collected from 7 transplantation centers in Turkey. Samples were tested for anti-hepatitis E virus immunoglobin M, immunoglobin G, and hepatitis E virus ribonucleic acid. Water- and food-related risk factors were evaluated by a questionnaire. Results: Samples of 300 kidney and 185 liver recipients were collected. Hepatitis E virus ribonucleic acid was tested in 472 samples and none were positive. Anti-hepatitis E virus immunoglobin G and immunoglobin M were detected in 84 (17.3%) and 3 (0.6%) patients, respectively. Seropositivity was associated with older age, male gender, being a liver recipient, and being infected with hepatitis B virus and/or hepatitis C virus. None of the patients under the age of 30 were seropositive. Hepatitis E virus immunoglobin G prevalence was higher in the Central East and Southeast Anatolia. Eating raw meat was the only independent variable associated with hepatitis E virus seropositivity. Conclusion: This is the first prevalence study of hepatitis E virus infection in solid organ recipients in Turkey. Anti-hepatitis E virus immunoglobin G prevalence was 17.3% which was higher than the previously reported rate in blood donors. Seropositivity was significantly higher in liver recipients. Despite the high antibody prevalence, none of the patients were viremic.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [216S904]; Dokuz Eylul University Scientific Research Coordination Unit [KB.SAG.035]en_US
dc.description.sponsorshipThis study was funded by TUBITAK (The Scientific and Technological Research Council of Turkey) under grant number 216S904 and Dokuz Eylul University Scientific Research Coordination Unit (project number: 2017.KB.SAG.035).en_US
dc.identifier.doi10.5152/tjg.2021.21071
dc.identifier.endpage73en_US
dc.identifier.issn2148-5607
dc.identifier.issue1en_US
dc.identifier.pmid35040790en_US
dc.identifier.scopus2-s2.0-85123651138en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.trdizinid523825en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2021.21071
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/523825
dc.identifier.urihttps://hdl.handle.net/11454/78904
dc.identifier.volume33en_US
dc.identifier.wosWOS:000744581000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis antibodiesen_US
dc.subjecthepatitis E virusen_US
dc.subjectkidney transplantationen_US
dc.subjectliver transplantationen_US
dc.subjectorgan transplantationen_US
dc.subjectE Virus-Infectionen_US
dc.subjectNationwide Surveyen_US
dc.subjectAntibodiesen_US
dc.titleHepatitis E Infection in Solid Organ Transplant Recipients in Turkeyen_US
dc.typeArticleen_US

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