Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex. © 2009 Springer Science+Business Media, LLC.
Açıklama
Anahtar Kelimeler
2,4-D, Herbicide, Histopathology, Kidney, Rat
Kaynak
Bulletin of Environmental Contamination and Toxicology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
82
Sayı
6
