Association of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patients

Basit Öğe Kaydı
dc.contributor.authorŞekuri C.
dc.contributor.authorÇam F.S.
dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.contributor.authorBayturan Ö.
dc.contributor.authorBerdeli A.
dc.date.accessioned2019-10-27T00:09:35Z
dc.date.available2019-10-27T00:09:35Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Platelet-activating factor (PAF) is a phospholipid with multiple actions that is involved in inflammatory diseases as well as in atherogenesis. It is inactivated by a plasma enzyme, PAF-acetylhydrolase (PAF-AH). Deficiency of this enzyme in plasma is caused by a missense mutation in the gene (G994T). The aim of this study was to investigate association of this mutation with premature coronary artery disease (CAD). Methods: One hundred and fifteen unrelated Turkish patients with a diagnosis of premature CAD and 128 unrelated healthy subjects were enrolled in this study. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The prevalence of the G994T mutation in the patients was 2.60 % (heterozygote), and 0 % in the controls. There was no significant difference in allele frequency and genotype distribution among the study groups. Conclusion: The G9943T mutation in the plasma PAF acetylhydrola se gene is not associated with premature CAD in Turkish subjects.en_US
dc.identifier.endpage134en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.pmid16766276en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://hdl.handle.net/11454/21721
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneen_US
dc.subjectPAF acetylhydrolaseen_US
dc.subjectPolymorphismen_US
dc.subjectPremature coronary artery diseaseen_US
dc.titleAssociation of platelet-activating factor acetylhydrolase gene polymorphism with premature coronary artery disease in Turkish patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu