Investigation of class-d beta-lactamases causing carbapenem resistance in clinical Acinetobacter baumannii isolates

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dc.contributor.authorDavandeh, Iskandar
dc.contributor.authorErac, Bayri
dc.contributor.authorAydemir, Sabire Sohret
dc.date.accessioned2019-10-27T11:19:41Z
dc.date.available2019-10-27T11:19:41Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: Acinetobacter baumannii is an important causative agent of nosocomial infections, and carbapenems have been frequently used in the treatment of these infections. This study was designed to investigate the prevalence of primary carbapenem hydrolyzing oxacillinase (CHO) types in clinical A. bumannii strains. Materials and methods: Minimum inhibitory concentration (MIC) values of 76 imipenem nonsusceptible A. baumannii strains, isolated from a tertiary care hospital, were determined by microdilution method. The clonal relationship of the isolates was analyzed with enterobacterial repetitive intergenic consensus (ERIC)-PCR, and the presence of CHO major groups (OXA-23; OXA-24, OXA-51, and OXA-58 groups) was investigated with multiplex PCR. Results: According to the ERIC-PCR patterns, the isolates were distributed in 13 different clones, the largest of which had 40 members. bla(OXA-51-group) was detected in representatives of all clones, whereas bla(OXA-23-group) was detected in representatives of all but two small clones. Additionally, the presence of bla(OXA-58-group) was discovered in the members of two small clones, whereas bla(OXA-24-group) was not encountered in any of the examined strains. Conclusion: Molecular fingerprinting revealed that most imipenem-resistant A. baumannii strains were clonally related. bla(OXA-23-group) and bla(OXA-51-group) were mostly responsible for the imipenem resistance of the examined A. baumannii strains.en_US
dc.description.sponsorshipScientific Research Council of Ege UniversityEge University [12/ECZ/027]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Council of Ege University (Grant No. 12/ECZ/027).en_US
dc.identifier.doi10.3906/sag-1607-91en_US
dc.identifier.endpage1666en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid29152950en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1661en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1607-91
dc.identifier.urihttps://hdl.handle.net/11454/32815
dc.identifier.volume47en_US
dc.identifier.wosWOS:000414976900048en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectcarbapenemaseen_US
dc.subjectenterobacterial repetitive intergenic consensus PCRen_US
dc.subjectOXA-genesen_US
dc.titleInvestigation of class-d beta-lactamases causing carbapenem resistance in clinical Acinetobacter baumannii isolatesen_US
dc.typeArticleen_US

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