Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty

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dc.contributor.authorGobeka, Hamidu
dc.contributor.authorSelver, Ozlem Barut
dc.contributor.authorOnay, Melis Palamar
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYagci, Ayse
dc.date.accessioned2019-10-27T10:03:38Z
dc.date.available2019-10-27T10:03:38Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To investigate the corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty (PKP). Materials and Methods: Thirty-five patients (70 eyes) were enrolled to this prospective study. Operated and contralateral keratoconic eyes were defined as Group 1 and 2, respectively. All patients underwent ophthalmological examination and measurements of corneal biomechanical properties by Ocular Response Analyzer (ORA), intraocular pressure (IOP) by Goldmann applanation tonometry, and central corneal thickness (CCT) by Pentacam. Shapiro-Wilk W test was performed to test normality of the data. The statistical significance was evaluated with the paired t-test and Wilcoxon signed ranks test. Pearson correlation and Spearman rho tests were used for correlation analysis. Results: The average age and male/female ratio were 31.34 +/- 11.65 (15-60) years and 21/14, respectively. The mean values of the data obtained from Group 1 and 2 respectively were: corneal hysteresis (CH): 9.35 +/- 1.66, 8.18 +/- 1.84 mmHg (p=0.013), corneal resistance factor (CRF): 9.48 +/- 1.96, 7.14 +/- 2.05 mmHg (p<0.001), IOPcc: 16.90 +/- 4.32, 14.26 +/- 3.69 mmHg (p=0.004), IOPg: 15.45 +/- 4.61, 10.91 +/- 3.97 mmHg (p<0.001), IOPapl: 14.26 +/- 3.11, 13.09 +/- 2.54 mmHg (p=0.046), and central corneal thickness (CCT): 545.64 +/- 60.82, 442.60 +/- 68.14 mu M (p<0.001). The positive correlation between CH and CRF was moderate (r=0.444) in Group 1 and strong (r=0.770) in Group 2. There was a moderate negative correlation between CH and IOPcc in both groups (r=-0.426, r=-0.423), but CH was not correlated with IOPg or IOPapl in either group. There were weak to strong positive correlations between CRF and all IOP values in both groups. There was no correlation between CRF and CCT in Group 1 (r=0.075) and a very weak correlation in Group 2 (r=0.237). Only IOPcc and IOPg were strongly correlated in both groups. Conclusion: Better understanding of corneal biomechanical properties is essential for elucidating the pathophysiology and diagnosis of several corneal pathologies such as keratoconus. The biomechanical properties of keratoconic eyes seem to be closer to normal values after PKP.en_US
dc.identifier.doi10.4274/tjo.79664
dc.identifier.endpage177en_US
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue4en_US
dc.identifier.pmid30202612en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.4274/tjo.79664
dc.identifier.urihttps://hdl.handle.net/11454/30139
dc.identifier.volume48en_US
dc.identifier.wosWOS:000443604600004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Ophthalmological Socen_US
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneal biomechanical propertiesen_US
dc.subjectOcular Response Analyzeren_US
dc.subjectkeratoconusen_US
dc.subjectpenetrating keratoplastyen_US
dc.titleCorneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplastyen_US
dc.typeArticleen_US

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