Influenza Vaccine: An Engineering Vision from Virological Importance to Production

Küçük Resim Yok

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Korean Soc Biotechnology & Bioengineering

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

According to data from the World Health Organization (WHO) every year, millions of people are affected by flu. Flu is a disease caused by influenza viruses. For preventing this, seasonal influenza vaccinations are widely considered the most efficient way to protect against the negative effects of the flu. To date, there is no one-size-fits-all vaccine that can be effective all over the world to protect against all seasonal or pandemic influenza virus types. Because influenza virus transforms its genetic structure and it can emerges as immunogenically new (antigenic drift) which causes epidemics or new virus subtype (antigenic shift) which causes pandemics. As a result, annual revaccination or new subtype viral vaccine development is required. Currently, three types of vaccines (inactivated, live attenuated, and recombinant) are approved in different countries. These can be named conventional influenza vaccines and their production are based on eggs or cell culture. Although, there is good effort to develop new influenza vaccines for broader and longer period of time protection. In this sense these candidate vaccines are called universal influenza vaccines. In this article, after we mentioned the short history of flu then virus morphology and infection, we explained the diseases caused by the influenza virus in humans. Afterward, we explained in detail the production methods of available influenza vaccines, types of bioreactors used in cell culture based production, conventional and new vaccine types, and development strategies for better vaccines.

Açıklama

Anahtar Kelimeler

influenza virus, influenza vaccine, vaccine manufacturing, cell culture-based vaccine production, vaccine production in bioreactors, influenza vaccine development strategies, Cell-Density Cultivations, Virus Production, A Virus, Mdck Cells, Perfusion, Progress, Culture, Adherent, Immunity, Innate

Kaynak

Biotechnology and Bioprocess Engineering

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

27

Sayı

5

Künye