Volumetric Cleft Changes in Treatment With Bone Morphogenic Protein/beta-Tricalcium Phosphate Versus Grafts From the Iliac Crest or Symphysis

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dc.contributor.authorTrujillo, Robert L.
dc.contributor.authorKadioglu, Onur
dc.contributor.authorCurrier, G. Frans
dc.contributor.authorSmith, Kevin S.
dc.contributor.authorYetkiner, Enver
dc.date.accessioned2019-10-27T10:03:11Z
dc.date.available2019-10-27T10:03:11Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To compare the volumetric changes in successfully treated clefts with secondary alveolar grafting using recombinant human bone morphogenic protein-2 (rhBMP-2) delivered in beta-tricalcium phosphate (beta TCP) scaffold versus autogenous grafts obtained from the iliac crest and mandibular symphysis. Patients and Methods: We performed a retrospective cohort study of cone-beam computed tomography scans of 25 subjects with unilateral or bilateral clefts. Of the 25 patients, 7 received an iliac crest bone graft, 9 received a mandibular symphyseal bone graft, and 9 subjects received the rhBMP-2/beta TCP bone substitute. Volumetric rendering software was used to calculate the amount of new bone formation and residual bone defect present in the cleft area. The data were analyzed using Wilcoxon and Kruskal-Wallis tests and Pearson's correlation coefficient. Results: The mean percentage of new bone formation for the iliac crest, symphysis, and rhBMP-2/i3TCP was 85.47, 80.56, and 81.22%, respectively (P = .0854). The initial cleft volume had a weak positive correlation with the percentage of new bone formation (r = 0.18), but the postoperative residual cleft volume had a strong negative correlation (r = 0.71). Conclusions: rhBMP2 delivered in a beta TCP scaffold in alveolar cleft patients can be a viable alternative to autogenous iliac crest and symphysis grafts, eliminating donor site morbidity. (C) 2018 American Association of Oral and Maxillofacial Surgeonsen_US
dc.identifier.doi10.1016/j.joms.2018.03.009en_US
dc.identifier.endpage1997en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue9en_US
dc.identifier.pmid29654774en_US
dc.identifier.startpage1991en_US
dc.identifier.urihttps://doi.org/10.1016/j.joms.2018.03.009
dc.identifier.urihttps://hdl.handle.net/11454/30081
dc.identifier.volume76en_US
dc.identifier.wosWOS:000442756400038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleVolumetric Cleft Changes in Treatment With Bone Morphogenic Protein/beta-Tricalcium Phosphate Versus Grafts From the Iliac Crest or Symphysisen_US
dc.typeArticleen_US

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