Volumetric Cleft Changes in Treatment With Bone Morphogenic Protein/beta-Tricalcium Phosphate Versus Grafts From the Iliac Crest or Symphysis
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To compare the volumetric changes in successfully treated clefts with secondary alveolar grafting using recombinant human bone morphogenic protein-2 (rhBMP-2) delivered in beta-tricalcium phosphate (beta TCP) scaffold versus autogenous grafts obtained from the iliac crest and mandibular symphysis. Patients and Methods: We performed a retrospective cohort study of cone-beam computed tomography scans of 25 subjects with unilateral or bilateral clefts. Of the 25 patients, 7 received an iliac crest bone graft, 9 received a mandibular symphyseal bone graft, and 9 subjects received the rhBMP-2/beta TCP bone substitute. Volumetric rendering software was used to calculate the amount of new bone formation and residual bone defect present in the cleft area. The data were analyzed using Wilcoxon and Kruskal-Wallis tests and Pearson's correlation coefficient. Results: The mean percentage of new bone formation for the iliac crest, symphysis, and rhBMP-2/i3TCP was 85.47, 80.56, and 81.22%, respectively (P = .0854). The initial cleft volume had a weak positive correlation with the percentage of new bone formation (r = 0.18), but the postoperative residual cleft volume had a strong negative correlation (r = 0.71). Conclusions: rhBMP2 delivered in a beta TCP scaffold in alveolar cleft patients can be a viable alternative to autogenous iliac crest and symphysis grafts, eliminating donor site morbidity. (C) 2018 American Association of Oral and Maxillofacial Surgeons
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Oral and Maxillofacial Surgery
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
76
Sayı
9
