Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers

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dc.authoridTelli, Fatma Cetin/0000-0003-2302-6409
dc.authorscopusid7003747438
dc.authorscopusid55357299600
dc.authorscopusid57204097891
dc.authorscopusid35310215400
dc.contributor.authorYildirim, Yeliz
dc.contributor.authorTelli, Fatma
dc.contributor.authorKahraman, Erkan
dc.contributor.authorGardiner, John M.
dc.date.accessioned2024-08-25T18:45:55Z
dc.date.available2024-08-25T18:45:55Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe synthesis of glycopolymers by copolymerising an allyl glucosamine (AG) monomer with co-monomers methyl methacrylate (MMA), acrylonitrile (AN) and 2-hydroxyethyl methacrylate (HEMA) was investigated via free-radical polymerisation of 2,2-azobisisobutyronitrile (AIBN) in dimethylformamide (DMF). Three new copolymers, poly(AG-co-MMA), poly(AG-co-AN) and poly(AG-co-HEMA), were obtained. The chemical structures of the glycopolymers were analysed using H-1-NMR, C-13-NMR and FTIR. The thermal properties and degradation kinetics of the three glycopolymers were examined by thermogravimetric (TG) analysis at different heating rates. The effects of different co-monomers on the copolymerisation yield, thermal properties and biological activities of the resulting glycopolymers were investigated. The activation energies of the decomposition stages were calculated using the Flynn-Wall-Ozawa (FWO) and Kissinger methods. Furthermore, the biological activity of AG monomers and glycopolymers was studied and compared to chitosan. Poly(AG-co-HEMA) had the most significant effect on MCF-7 cell viability, and all glycopolymers have a low toxic effect profile on MCF-7 cell lines.en_US
dc.description.sponsorshipEge University's Scientific Research Projects Coordination Unit [FGA-2020-21474]; TUBITAK (Scientific and Technical Research Council of Turkey) [BIDEB-2219]en_US
dc.description.sponsorshipAcknowledgments This study was supported by Ege University's Scientific Research Projects Coordination Unit with Project number FGA-2020-21474. Fatma Telli received a grant from the TUBITAK (Scientific and Technical Research Council of Turkey) BIDEB-2219 Programme for a postdoctoral fellowship.en_US
dc.identifier.doi10.1080/15685551.2023.2199506
dc.identifier.endpage131en_US
dc.identifier.issn1385-772X
dc.identifier.issn1568-5551
dc.identifier.issue1en_US
dc.identifier.pmid37064216en_US
dc.identifier.scopus2-s2.0-85152768976en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1080/15685551.2023.2199506
dc.identifier.urihttps://hdl.handle.net/11454/101722
dc.identifier.volume26en_US
dc.identifier.wosWOS:000969365600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDesigned Monomers and Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectGlycopolymersen_US
dc.subjectcarbohydrate-based allyl copolymeren_US
dc.subjectdecomposition kineticen_US
dc.subjectthermal analysisen_US
dc.subjectbiological applicationsen_US
dc.subjectThermal-Degradationen_US
dc.subjectChitosanen_US
dc.subjectCopolymersen_US
dc.subjectPolymerizationen_US
dc.subjectAcrylonitrileen_US
dc.subjectPolymersen_US
dc.subjectPolyacrylonitrileen_US
dc.subjectDerivativesen_US
dc.subjectBiopolymeren_US
dc.subjectMembranesen_US
dc.titleSynthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymersen_US
dc.typeArticleen_US

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