Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The synthesis of glycopolymers by copolymerising an allyl glucosamine (AG) monomer with co-monomers methyl methacrylate (MMA), acrylonitrile (AN) and 2-hydroxyethyl methacrylate (HEMA) was investigated via free-radical polymerisation of 2,2-azobisisobutyronitrile (AIBN) in dimethylformamide (DMF). Three new copolymers, poly(AG-co-MMA), poly(AG-co-AN) and poly(AG-co-HEMA), were obtained. The chemical structures of the glycopolymers were analysed using H-1-NMR, C-13-NMR and FTIR. The thermal properties and degradation kinetics of the three glycopolymers were examined by thermogravimetric (TG) analysis at different heating rates. The effects of different co-monomers on the copolymerisation yield, thermal properties and biological activities of the resulting glycopolymers were investigated. The activation energies of the decomposition stages were calculated using the Flynn-Wall-Ozawa (FWO) and Kissinger methods. Furthermore, the biological activity of AG monomers and glycopolymers was studied and compared to chitosan. Poly(AG-co-HEMA) had the most significant effect on MCF-7 cell viability, and all glycopolymers have a low toxic effect profile on MCF-7 cell lines.
Açıklama
Anahtar Kelimeler
Glycopolymers, carbohydrate-based allyl copolymer, decomposition kinetic, thermal analysis, biological applications, Thermal-Degradation, Chitosan, Copolymers, Polymerization, Acrylonitrile, Polymers, Polyacrylonitrile, Derivatives, Biopolymer, Membranes
Kaynak
Designed Monomers and Polymers
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
26
Sayı
1
