Iron Chelation Therapy as a Modality of Management

dc.contributor.authorAydinok, Yesim
dc.date.accessioned2019-10-27T10:41:55Z
dc.date.available2019-10-27T10:41:55Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction of MRI techniques for identifying and monitoring tissue iron overload and the current understanding of iron homeostasis in transfusion-dependent (TDT) and non transfusion-dependent thalassemia have allowed for a more robust administration of iron chelation therapies. The development of safe and efficient oral iron chelators and the insights gained from large-scale prospective studies using these agents have improved iron overload management. A significant reduction in iron toxicity induced morbidity and mortality and improvements in quality of life were observed in TDT. The appropriate management of tissue-specific iron loading in TDT has been portrayed using evidence-based data obtained from investigational studies.en_US
dc.description.sponsorshipNovartis Pharmaceuticals; Cerus; Celgene; Shireen_US
dc.description.sponsorshipReceiving research grant funding, consulting fees, and lecture fees from Novartis Pharmaceuticals, research grant funding and lecture fees from Cerus, research grant funding from Celgene and Shire.en_US
dc.identifier.doi10.1016/j.hoc.2017.12.002en_US
dc.identifier.endpage+en_US
dc.identifier.issn0889-8588
dc.identifier.issn1558-1977
dc.identifier.issue2en_US
dc.identifier.pmid29458731en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1016/j.hoc.2017.12.002
dc.identifier.urihttps://hdl.handle.net/11454/30551
dc.identifier.volume32en_US
dc.identifier.wosWOS:000428462100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofHematology-Oncology Clinics of North Americaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThalassemia majoren_US
dc.subjectThalassemia intermediaen_US
dc.subjectTransfusion-dependent thalassemiaen_US
dc.subjectNon-transfusion dependent thalassemiaen_US
dc.subjectChelationen_US
dc.subjectLiver iron concentrationen_US
dc.subjectCardiac ironen_US
dc.subjectSerum ferritinen_US
dc.titleIron Chelation Therapy as a Modality of Managementen_US
dc.typeArticleen_US

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