Iron Chelation Therapy as a Modality of Management
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction of MRI techniques for identifying and monitoring tissue iron overload and the current understanding of iron homeostasis in transfusion-dependent (TDT) and non transfusion-dependent thalassemia have allowed for a more robust administration of iron chelation therapies. The development of safe and efficient oral iron chelators and the insights gained from large-scale prospective studies using these agents have improved iron overload management. A significant reduction in iron toxicity induced morbidity and mortality and improvements in quality of life were observed in TDT. The appropriate management of tissue-specific iron loading in TDT has been portrayed using evidence-based data obtained from investigational studies.
Açıklama
Anahtar Kelimeler
Thalassemia major, Thalassemia intermedia, Transfusion-dependent thalassemia, Non-transfusion dependent thalassemia, Chelation, Liver iron concentration, Cardiac iron, Serum ferritin
Kaynak
Hematology-Oncology Clinics of North America
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
32
Sayı
2
