The prognostic significance of clinicopathological features and apoptosis inhibitor proteins in pancreas ductal adenocarcinoma

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dc.contributor.authorArgon, Asuman
dc.contributor.authorNart, Deniz
dc.contributor.authorOruc, Nevin
dc.contributor.authorCoker, Ahmet
dc.contributor.authorOzutemiz, Omer
dc.date.accessioned2019-10-27T22:14:33Z
dc.date.available2019-10-27T22:14:33Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction : Pancreas ductal adenocarcinoma (PDAC) is among tumors with unfavorable prognosis. The aim of this study was to determine potential prognostic factors in PDAC. Materials and methods : We retrospectively evaluated a total of 117 cases according to clinicopathological parameters and survivin and livin expression. We investigated the relationship between these parameters and their prognostic significance. Results : In univariate analysis, lymph node metastasis, surgical margin positivity, tumor size over 4 cm and survivin expression were associated with poorer survival but livin expression was not correlated with survival-time. In multivariate analysis, only lymph node metastasis was independent factor predicting a poorer outcome. Conclusions : In present study, the lymph node metastasis was the strongest predictor of survival. Our finding suggest that survivin could be a target for the treatment of advanced stage resectable PDAC. Our results need to be supported by studies on larger series with advanced techniques.en_US
dc.identifier.endpage234en_US
dc.identifier.issn0001-5644
dc.identifier.issn1477-4607
dc.identifier.issue2en_US
dc.identifier.pmid25090821en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage229en_US
dc.identifier.urihttps://hdl.handle.net/11454/50029
dc.identifier.volume77en_US
dc.identifier.wosWOS:000341234800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpancreas ductal adenocarcinomaen_US
dc.subjectapoptosis inhibitor proteinsen_US
dc.subjectprognosisen_US
dc.subjectSurvivinen_US
dc.subjectLivinen_US
dc.titleThe prognostic significance of clinicopathological features and apoptosis inhibitor proteins in pancreas ductal adenocarcinomaen_US
dc.typeArticleen_US

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