The prognostic significance of clinicopathological features and apoptosis inhibitor proteins in pancreas ductal adenocarcinoma
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Catholique Louvain-Ucl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction : Pancreas ductal adenocarcinoma (PDAC) is among tumors with unfavorable prognosis. The aim of this study was to determine potential prognostic factors in PDAC. Materials and methods : We retrospectively evaluated a total of 117 cases according to clinicopathological parameters and survivin and livin expression. We investigated the relationship between these parameters and their prognostic significance. Results : In univariate analysis, lymph node metastasis, surgical margin positivity, tumor size over 4 cm and survivin expression were associated with poorer survival but livin expression was not correlated with survival-time. In multivariate analysis, only lymph node metastasis was independent factor predicting a poorer outcome. Conclusions : In present study, the lymph node metastasis was the strongest predictor of survival. Our finding suggest that survivin could be a target for the treatment of advanced stage resectable PDAC. Our results need to be supported by studies on larger series with advanced techniques.
Açıklama
Anahtar Kelimeler
pancreas ductal adenocarcinoma, apoptosis inhibitor proteins, prognosis, Survivin, Livin
Kaynak
Acta Gastro-Enterologica Belgica
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
77
Sayı
2
