Diverse effects of calcium channel blockers in the collar model

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dc.contributor.authorKerry, Z
dc.contributor.authorYasa, M
dc.contributor.authorSevin, G
dc.contributor.authorReel, B
dc.contributor.authorAnacak, GY
dc.contributor.authorOzer, A
dc.date.accessioned2019-10-27T19:22:40Z
dc.date.available2019-10-27T19:22:40Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective - Calcium channel blockers (CCBs) are among the most frequently prescribed cardiovascular drugs. It has been shown that these drugs have antiatherosclerotic effects in both experimental and clinical settings. However, calcium channel blockers have markedly different chemical structures and different effects on the cardiovascular system.We investigated the effect of CD-832, a Ca+2 channel antagonist, on collar-induced intimal thickening, as well as accompanied reactivity changes in rabbit carotid artery. Methods and results - Rabbits received 5 mg/kg/day CD-832 or vehicle (polyethylene glycol, 0.5 ml/kg/day) intramuscularly for a week before and 2 weeks after the collar application. Histological and isometric force measurements were performed in segments from sham and collared carotid arteries. A three-week treatment with CD-832 did not inhibit the intimal thickening caused by perivascular application of a silicone collar. Potassium chloride (KCI), phenylephrine, 5-hydroxytryptamine (5-HT, serotonin) and histamine induced concentration-dependent contractions in both sham-operated (sham) and collared arteries. Collar-induced attenuations in maximum KCI, histamine, phenylephrine and 5-HT contractions were not affected by CD-832. Collaring caused an increase in pD(2) values of 5-HT and a decrease in those of phenylephrine, histamine and acetylcholine. CD-832 did not affect the altered sensitivity to these agonists. Conclusions -These results demonstrate that, in rabbit carotid artery, CD-832 did not inhibit the collar-induced intimal thickening and did not affect the accompanying changes in vascular reactivity.en_US
dc.identifier.doi10.2143/AC.60.5.2004970en_US
dc.identifier.endpage499en_US
dc.identifier.issn0001-5385
dc.identifier.issue5en_US
dc.identifier.pmid16261780en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage493en_US
dc.identifier.urihttps://doi.org/10.2143/AC.60.5.2004970
dc.identifier.urihttps://hdl.handle.net/11454/39109
dc.identifier.volume60en_US
dc.identifier.wosWOS:000232558700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalcium channel blockeren_US
dc.subjectintimal thickeningen_US
dc.subjectrabbiten_US
dc.subjectvascular reactivityen_US
dc.subjectcollar modelen_US
dc.subjectCD-832en_US
dc.titleDiverse effects of calcium channel blockers in the collar modelen_US
dc.typeArticleen_US

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