Diverse effects of calcium channel blockers in the collar model
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Cardiologica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective - Calcium channel blockers (CCBs) are among the most frequently prescribed cardiovascular drugs. It has been shown that these drugs have antiatherosclerotic effects in both experimental and clinical settings. However, calcium channel blockers have markedly different chemical structures and different effects on the cardiovascular system.We investigated the effect of CD-832, a Ca+2 channel antagonist, on collar-induced intimal thickening, as well as accompanied reactivity changes in rabbit carotid artery. Methods and results - Rabbits received 5 mg/kg/day CD-832 or vehicle (polyethylene glycol, 0.5 ml/kg/day) intramuscularly for a week before and 2 weeks after the collar application. Histological and isometric force measurements were performed in segments from sham and collared carotid arteries. A three-week treatment with CD-832 did not inhibit the intimal thickening caused by perivascular application of a silicone collar. Potassium chloride (KCI), phenylephrine, 5-hydroxytryptamine (5-HT, serotonin) and histamine induced concentration-dependent contractions in both sham-operated (sham) and collared arteries. Collar-induced attenuations in maximum KCI, histamine, phenylephrine and 5-HT contractions were not affected by CD-832. Collaring caused an increase in pD(2) values of 5-HT and a decrease in those of phenylephrine, histamine and acetylcholine. CD-832 did not affect the altered sensitivity to these agonists. Conclusions -These results demonstrate that, in rabbit carotid artery, CD-832 did not inhibit the collar-induced intimal thickening and did not affect the accompanying changes in vascular reactivity.
Açıklama
Anahtar Kelimeler
calcium channel blocker, intimal thickening, rabbit, vascular reactivity, collar model, CD-832
Kaynak
Acta Cardiologica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
60
Sayı
5
