Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells

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dc.contributor.authorKonyalioglu, Sibel
dc.contributor.authorArmagan, Guliz
dc.contributor.authorYalcin, Ayfer
dc.contributor.authorAtalayin, Cigdem
dc.contributor.authorDagci, Taner
dc.date.accessioned2019-10-27T21:41:44Z
dc.date.available2019-10-27T21:41:44Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractResveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.en_US
dc.description.sponsorshipTurkish Scientific and Technological Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Research Fund of Ege UniversityEge University [05/ECZ/020]en_US
dc.description.sponsorshipGuliz Armagan acknowledges a scholarship for postgraduate students obtained from the Turkish Scientific and Technological Council (TUBITAK).; This study was funded by the Research Fund of Ege University, Project No. 05/ECZ/020.en_US
dc.identifier.doi10.3969/j.issn.1673-5374.2013.06.001en_US
dc.identifier.endpage495en_US
dc.identifier.issn1673-5374
dc.identifier.issue6en_US
dc.identifier.pmid25206691en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage485en_US
dc.identifier.urihttps://doi.org/10.3969/j.issn.1673-5374.2013.06.001
dc.identifier.urihttps://hdl.handle.net/11454/46735
dc.identifier.volume8en_US
dc.identifier.wosWOS:000315936300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherShenyang Editorial Dept Neural Regeneration Resen_US
dc.relation.ispartofNeural Regeneration Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneural regenerationen_US
dc.subjecttraditional Chinese medicineen_US
dc.subjectstem cellsen_US
dc.subjectresveratrolen_US
dc.subjectembryonic neural stem cellsen_US
dc.subjecthydrogen peroxideen_US
dc.subjectcatalaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectnitric oxide synthaseen_US
dc.subjectnitric oxideen_US
dc.subjectDNA damageen_US
dc.subjectneuroprotectionen_US
dc.subjectgrants-supported paperen_US
dc.subjectneuroregenerationen_US
dc.titleEffects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cellsen_US
dc.typeArticleen_US

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