Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Shenyang Editorial Dept Neural Regeneration Res
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Resveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.
Açıklama
Anahtar Kelimeler
neural regeneration, traditional Chinese medicine, stem cells, resveratrol, embryonic neural stem cells, hydrogen peroxide, catalase, glutathione peroxidase, nitric oxide synthase, nitric oxide, DNA damage, neuroprotection, grants-supported paper, neuroregeneration
Kaynak
Neural Regeneration Research
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
8
Sayı
6
