Left ventricular diastolic abnormalities in children with ß-thalassemia major: A doopler echocardiographic study

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dc.contributor.authorYaprak I.
dc.contributor.authorAkşit S.
dc.contributor.authorÖztürk C.
dc.contributor.authorBakiler A.R.
dc.contributor.authorDorak C.
dc.contributor.authorTürker M.
dc.date.accessioned2019-10-27T00:31:55Z
dc.date.available2019-10-27T00:31:55Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractLeft ventricular filling patterns were assessed by Doppler echocardiography in 63 ß-thalassemia major patients, aged for to 21 years, with no clinical evidence of congestive heart failure and 63 age- and sex-matched normal controls. The patients with ß-thalassemla major were divided into three age groups, namely four to nine years (6.8 ± 1.5 years), 10-15 years (12.1 ± 1.6 years) and older than 15 years (17.3 ± 1.7 years). They were compared with age- and sex-matched normal controls in respects of Doopler diastolic indices. The ratio between the early and late (atrial) peaks of flow velocity was higher and peak flow velocity in late diastole was significantly lower in patients with ß-thalassemia major as compared to controls in all three age groups (p < .001). As compared with the controls, peak early diastolic flow velocity was also significantly higher in the thalassemics aged 10 to 15 years (92 ± 16 vs 80 ± 12 cm/s, P < .01) and in those older than 15 years (95 ± 16 vs 79 ± 13 cm/s, p<.001). Restrictive left ventricular diastolic abnormalities were detected in a total of 34 (54%) patients with ß-thalassemia major, whereas left ventricular systolic abnormalities were identified only eight (13%) of them. None of the patients without left ventricular diastolic abnormalities showed left ventricular systolic abnormalities. There was not any significant correlation between the hematologic parameters, such as mean serum ferritin, maximum serum ferritin and the number of blood units transfused, and left ventricular Doopler diastolic indices (p>.05). From the data presented here, we therefore conclude that left ventricular diastolic abnormalities develop in patients with ß-thalassemia major in the early phase of the disease and before the apearance of systolic abnormalities, when clinical symptoms of congestive heart failure are absent.en_US
dc.identifier.endpage209en_US
dc.identifier.issn0041-4301
dc.identifier.issue2en_US
dc.identifier.pmid9677725en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/11454/23604
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectß-thalassemia majoren_US
dc.subjectDoopleren_US
dc.subjectEchocardiographyen_US
dc.subjectLeft ventricular fillingen_US
dc.titleLeft ventricular diastolic abnormalities in children with ß-thalassemia major: A doopler echocardiographic studyen_US
dc.typeArticleen_US

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