Left ventricular diastolic abnormalities in children with ß-thalassemia major: A doopler echocardiographic study
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Left ventricular filling patterns were assessed by Doppler echocardiography in 63 ß-thalassemia major patients, aged for to 21 years, with no clinical evidence of congestive heart failure and 63 age- and sex-matched normal controls. The patients with ß-thalassemla major were divided into three age groups, namely four to nine years (6.8 ± 1.5 years), 10-15 years (12.1 ± 1.6 years) and older than 15 years (17.3 ± 1.7 years). They were compared with age- and sex-matched normal controls in respects of Doopler diastolic indices. The ratio between the early and late (atrial) peaks of flow velocity was higher and peak flow velocity in late diastole was significantly lower in patients with ß-thalassemia major as compared to controls in all three age groups (p < .001). As compared with the controls, peak early diastolic flow velocity was also significantly higher in the thalassemics aged 10 to 15 years (92 ± 16 vs 80 ± 12 cm/s, P < .01) and in those older than 15 years (95 ± 16 vs 79 ± 13 cm/s, p<.001). Restrictive left ventricular diastolic abnormalities were detected in a total of 34 (54%) patients with ß-thalassemia major, whereas left ventricular systolic abnormalities were identified only eight (13%) of them. None of the patients without left ventricular diastolic abnormalities showed left ventricular systolic abnormalities. There was not any significant correlation between the hematologic parameters, such as mean serum ferritin, maximum serum ferritin and the number of blood units transfused, and left ventricular Doopler diastolic indices (p>.05). From the data presented here, we therefore conclude that left ventricular diastolic abnormalities develop in patients with ß-thalassemia major in the early phase of the disease and before the apearance of systolic abnormalities, when clinical symptoms of congestive heart failure are absent.
Açıklama
Anahtar Kelimeler
ß-thalassemia major, Doopler, Echocardiography, Left ventricular filling
Kaynak
Turkish Journal of Pediatrics
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
40
Sayı
2
