Diagnostic value of serum procalcitonin in determining the activity of inflammatory bowel disease

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dc.contributor.authorOruc, Nevin
dc.contributor.authorOezuetemiz, Oemer
dc.contributor.authorOsmanoglu, Necla
dc.contributor.authorIlter, Tankut
dc.date.accessioned2019-10-27T20:19:18Z
dc.date.available2019-10-27T20:19:18Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aims: Procalcitonin and C-reactive protein are two acute-phase reactant proteins, although procalcitonin is a more specific marker for bacterial infections. Procalcitonin level might also be helpful to predict the disease activity of inflammatory bowel disease. This study aimed to compare the diagnostic value of serum procalcitonin and C-reactive protein as indicators of disease activity in inflammatory bowel disease. Methods: Patients admitted to the inflammatory bowel disease inpatient clinic with suspected inflammatory bowel disease who had not yet been treated with immunosuppressive treatments were included. Disease activity, white blood cell count, sedimentation rate, serum procalcitonin and C-reactive protein levels were evaluated in 45 newly diagnosed inflammatory bowel disease patients (9 Crohn's disease and 36 ulcerative colitis). Fifty healthy volunteers were analyzed as a control group. Results: Crohn's disease patients had higher procalcitonin and C-reactive protein levels than healthy controls (Procalcitonin: 0.143 +/- 0.081 us. 0.065 +/- 0.008 ng/ml, p<0.05; C-reactive protein: 29 +/- 7.5 vs. 2.9 +/- 0.5 mg/dl, p<0.001, respectively). Ulcerative colitis patients also had slightly higher procalcitonin levels and significantly higher C-reactive protein levels than controls (Procalcitonin: 0.107 +/- 0.042 ng/ml; C-reactive protein: 23 +/- 5.5 mg/dl). Two Crohn's disease patients had procalcitonin value above 1 ng/ml. Receiver operating characteristic curve analysis demonstrated that C-reactive protein is the best marker of disease activity in inflammatory bowel disease while procalcitonin has low sensitivity and specificity. Serum procalcitonin levels were highly correlated with serum C-reactive protein but no other disease activity parameters. Conclusions: Although still within normal ranges, procalcitonin levels were slightly elevated in Crohn's disease but not in ulcerative colitis patients compared to healthy controls. Serum C-reactive protein is a reliable marker for disease activity in inflammatory bowel disease. Procalcitonin has no diagnostic value in determining disease activity.en_US
dc.identifier.endpage12en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.pmid19330729en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/11454/41390
dc.identifier.volume20en_US
dc.identifier.wosWOS:000265416700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Gastroenterologyen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProcalcitoninen_US
dc.subjectC-reactive proteinen_US
dc.subjectCrohn's diseaseen_US
dc.subjectulcerative colitisen_US
dc.titleDiagnostic value of serum procalcitonin in determining the activity of inflammatory bowel diseaseen_US
dc.typeArticleen_US

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