Long-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experience

dc.contributor.authorBulut I.K.
dc.contributor.authorTaner S.
dc.contributor.authorKeskinoglu A.
dc.contributor.authorToz H.
dc.contributor.authorSarsik B.
dc.contributor.authorSezer T.O.
dc.contributor.authorKabasakal C.
dc.date.accessioned2019-10-26T21:12:18Z
dc.date.available2019-10-26T21:12:18Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction and Aim: Focal segmental glomerulosclerosis (FSGS)is a common cause of end-stage renal disease in children. We analyzed the long-term outcome of pediatric patients with FSGS undergoing renal transplantation. The objective of the study is to report the experience of a single center and determine the incidence of recurrence, rejection, graft loss, and related risk factors. Materials and Method: This retrospective cohort study was performed between 1991 and 2018. Thirty patients with a pathologic diagnosis of primary FSGS were included in the study. The patients were diagnosed with FSGS according to histologic features in biopsies. Results: Twenty-one of the donors were deceased (70%)and 9 were alive (30%). FSGS recurred in only 2 patients. Graft loss occurred in 6 patients (20%). The causes of graft loss were chronic rejection in 4 patients and acute rejection in 2. Our graft survival rate was 100% at 1 year, 91% at 5 years, 80% at 10 years, 70% at 15 years, and 42% at 20 years. Five- and 10-year graft survival rates were 83% and 83% in living donors and 94% and 79% in deceased donors, respectively. According to Kaplan-Meier analysis, there was no statistically significant difference in terms of graft survival between living and deceased donors. Conclusion: This study, with its contribution to literature in terms of long follow-up of FSGS patients from childhood to adulthood, is important. However, further studies are required. © 2019 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.transproceed.2019.01.096en_US
dc.identifier.endpage1069en_US
dc.identifier.issn0041-1345
dc.identifier.issue4en_US
dc.identifier.pmid31101172en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1064en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2019.01.096
dc.identifier.urihttps://hdl.handle.net/11454/15663
dc.identifier.volume51en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier USAen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLong-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experienceen_US
dc.typeArticleen_US

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