Long-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experience
dc.contributor.author | Bulut I.K. | |
dc.contributor.author | Taner S. | |
dc.contributor.author | Keskinoglu A. | |
dc.contributor.author | Toz H. | |
dc.contributor.author | Sarsik B. | |
dc.contributor.author | Sezer T.O. | |
dc.contributor.author | Kabasakal C. | |
dc.date.accessioned | 2019-10-26T21:12:18Z | |
dc.date.available | 2019-10-26T21:12:18Z | |
dc.date.issued | 2019 | |
dc.department | Ege Üniversitesi | en_US |
dc.description.abstract | Introduction and Aim: Focal segmental glomerulosclerosis (FSGS)is a common cause of end-stage renal disease in children. We analyzed the long-term outcome of pediatric patients with FSGS undergoing renal transplantation. The objective of the study is to report the experience of a single center and determine the incidence of recurrence, rejection, graft loss, and related risk factors. Materials and Method: This retrospective cohort study was performed between 1991 and 2018. Thirty patients with a pathologic diagnosis of primary FSGS were included in the study. The patients were diagnosed with FSGS according to histologic features in biopsies. Results: Twenty-one of the donors were deceased (70%)and 9 were alive (30%). FSGS recurred in only 2 patients. Graft loss occurred in 6 patients (20%). The causes of graft loss were chronic rejection in 4 patients and acute rejection in 2. Our graft survival rate was 100% at 1 year, 91% at 5 years, 80% at 10 years, 70% at 15 years, and 42% at 20 years. Five- and 10-year graft survival rates were 83% and 83% in living donors and 94% and 79% in deceased donors, respectively. According to Kaplan-Meier analysis, there was no statistically significant difference in terms of graft survival between living and deceased donors. Conclusion: This study, with its contribution to literature in terms of long follow-up of FSGS patients from childhood to adulthood, is important. However, further studies are required. © 2019 Elsevier Inc. | en_US |
dc.identifier.doi | 10.1016/j.transproceed.2019.01.096 | en_US |
dc.identifier.endpage | 1069 | en_US |
dc.identifier.issn | 0041-1345 | |
dc.identifier.issue | 4 | en_US |
dc.identifier.pmid | 31101172 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 1064 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.transproceed.2019.01.096 | |
dc.identifier.uri | https://hdl.handle.net/11454/15663 | |
dc.identifier.volume | 51 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier USA | en_US |
dc.relation.ispartof | Transplantation Proceedings | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Long-Term Follow-up Results of Renal Transplantation in Pediatric Patients With Focal Segmental Glomerulosclerosis: A Single-Center Experience | en_US |
dc.type | Article | en_US |