A novel DAD type and folic acid conjugated fluorescent monomer as a targeting probe for imaging of folate receptor overexpressed cells

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

John Wiley and Sons Inc.

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

We describe a modification and post-functionalization technique for a donor-acceptor-donor type monomer; 6-(4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2H-benzo[d][1,2, 3]triazol-2-yl)hexan-1-amine. Folic acid was attached to the fluorescent structure. The conjugation was confirmed via NMR and Fourier transform infrared analyses. Cytotoxicity was investigated and the comparison of association of targeted monomeric structures in tumor cells was monitored via fluorescence microscopy. © 2014 American Institute of Chemical Engineers.

Açıklama

Anahtar Kelimeler

Cell imaging, Conjugation, Fluorescence microscopy, Folic acid

Kaynak

Biotechnology Progress

WoS Q Değeri

Scopus Q Değeri

Q2

Cilt

30

Sayı

4

Künye