Dry eye and Meibomian gland dysfunction with meibography in patients with lamellar ichthyosis

Basit Öğe Kaydı
dc.contributor.authorPalamar, Melis
dc.contributor.authorKaraca, Irmak
dc.contributor.authorOnay, Huseyin
dc.contributor.authorErtam, Ilgen
dc.contributor.authorYagci, Ayse
dc.date.accessioned2019-10-27T10:41:56Z
dc.date.available2019-10-27T10:41:56Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To evaluate the dry eye findings and Meibomian gland dysfunction as demonstrated with meibography in patients with lamellar ichthyosis. Methods: Twenty-four eyes of 12 patients with lamellar ichthyosis (Group 1) and twenty-four eyes of 12 healthy individuals (Group 2) were enrolled. Comprehensive eye examination along with corneal and conjunctival fluorescein staining with Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of upper and lower eyelid Meibomian glands using infrared filter of slit-lamp biomicroscope (SL-D701, TOPCON, Tokyo, Japan) were performed. The Meibomian glands were graded from grade 0 (no loss of Meibomian glands) to grade 3 (gland dropout > 2/3 of the total Meibomian glands). Results: The mean ages of Group 1 and Group 2 were 25.3 +/- 15.6 years (range, 9-61 years) and 25.3 +/- 13.3 years (range, 9-52 years), respectively (p = 0.997). No significant difference in terms of best-corrected visual acuity, Schirmer 1 test and Oxford scores were detected in between groups. Mean tear film break-up time was lower (p = 0.013), and OSDI score, lower, upper and total (upper + lower) meiboscores were significantly higher in Group 1 as compared with Group 2 (p < 0.001, p = 0.001, p = 0.001, p = 0.001, respectively). Conclusion: Lamellar ichthyosis is associated with evaporative type dry eye disease with decreased tear film break-up time, normal Schirmer 1 values and Meibomian gland dysfunction that can objectively be demonstrated with meibography. For this reason, in order to prevent undesired complications, these patients should be examined and treated for dry eye disease especially targeting Meibomian gland dysfunction.en_US
dc.description.sponsorshipEuropean Soc Cataract & Refract Surgen_US
dc.identifier.doi10.1016/j.clae.2017.06.001en_US
dc.identifier.endpage156en_US
dc.identifier.issn1367-0484
dc.identifier.issn1476-5411
dc.identifier.issue2en_US
dc.identifier.pmid28645677en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage154en_US
dc.identifier.urihttps://doi.org/10.1016/j.clae.2017.06.001
dc.identifier.urihttps://hdl.handle.net/11454/30557
dc.identifier.volume41en_US
dc.identifier.wosWOS:000428127100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofContact Lens & Anterior Eyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDry eyeen_US
dc.subjectOcular surfaceen_US
dc.subjectMeibomian gland dysfunctionen_US
dc.subjectMeibographyen_US
dc.subjectLamellar ichthyosisen_US
dc.titleDry eye and Meibomian gland dysfunction with meibography in patients with lamellar ichthyosisen_US
dc.typeArticleen_US

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