Dry eye and Meibomian gland dysfunction with meibography in patients with lamellar ichthyosis
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To evaluate the dry eye findings and Meibomian gland dysfunction as demonstrated with meibography in patients with lamellar ichthyosis. Methods: Twenty-four eyes of 12 patients with lamellar ichthyosis (Group 1) and twenty-four eyes of 12 healthy individuals (Group 2) were enrolled. Comprehensive eye examination along with corneal and conjunctival fluorescein staining with Oxford scoring, tear film break-up time, Schirmer 1 test, ocular surface disease index (OSDI) score assessment, and evaluation of upper and lower eyelid Meibomian glands using infrared filter of slit-lamp biomicroscope (SL-D701, TOPCON, Tokyo, Japan) were performed. The Meibomian glands were graded from grade 0 (no loss of Meibomian glands) to grade 3 (gland dropout > 2/3 of the total Meibomian glands). Results: The mean ages of Group 1 and Group 2 were 25.3 +/- 15.6 years (range, 9-61 years) and 25.3 +/- 13.3 years (range, 9-52 years), respectively (p = 0.997). No significant difference in terms of best-corrected visual acuity, Schirmer 1 test and Oxford scores were detected in between groups. Mean tear film break-up time was lower (p = 0.013), and OSDI score, lower, upper and total (upper + lower) meiboscores were significantly higher in Group 1 as compared with Group 2 (p < 0.001, p = 0.001, p = 0.001, p = 0.001, respectively). Conclusion: Lamellar ichthyosis is associated with evaporative type dry eye disease with decreased tear film break-up time, normal Schirmer 1 values and Meibomian gland dysfunction that can objectively be demonstrated with meibography. For this reason, in order to prevent undesired complications, these patients should be examined and treated for dry eye disease especially targeting Meibomian gland dysfunction.
Açıklama
Anahtar Kelimeler
Dry eye, Ocular surface, Meibomian gland dysfunction, Meibography, Lamellar ichthyosis
Kaynak
Contact Lens & Anterior Eye
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
41
Sayı
2
