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Öğe The (-174) G/C polymorphism in the interleukin-6 gene is associated with risk of papillary thyroid carcinoma in Turkish patients(Springer, 2009) Ozgen, A. G.; Karadeniz, M.; Erdogan, M.; Berdeli, A.; Saygili, F.; Yilmaz, C.Introduction: Interleukins and cytokines play an important role in the pathogenesis of many cancers. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in patients with papillary thyroid carcinoma (PTC) and control subjects. Material and methods: In this study, 42 patients with PTC and 340 healthy controls were included. Peripheral blood samples were taken from control group and patients, and blood samples were preserved at -80 C in tubes containing Na-EDTA. Results: We also found a statistically significant difference between patients with PTC and the control group with respect to IL-6 genotype (p<0.05). IL-6 gene polymorphism in patients with PTC patients did not reveal statistically significant difference between the 2 groups (size of tumor >1 cm and <1 cm), multicentricity, RET-PTC types and capsule invasion (p>0.05). We also did not find a statistically significant difference between patients with PTC and the control group with respect to IL-6-gene allele frequency (p>0.05). Discussion: Our data suggest that the IL-6 G-174 C polymorphism could play a role in thyroid cancer risk, but there is no effective role as a prognostic factor. (J. Endocrinol. Invest. 32: 491-494, 2009) (C) 2009, Editrice KurtisÖğe Acromegaly is associated with high fibroblast growth factor-21 levels(Springer, 2019) Yurekli, B. S.; Kutbay, N. O.; Aksit, M.; Suner, A.; Simsir, I. Y.; Seckiner, S.; Kocabas, G. U.; Bozkaya, G.; Saygili, F.PurposeFibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition.MethodsWe studied 43 subjects (21 females and 22 males, mean age of 50.012.8) with acromegaly. The control group consisted of 40 gender- and age-matched subjects (25 females and 15 males, mean age of 48.88.8). Acromegaly patients were classified into two groups; active acromegaly (AA; n=26) and controlled acromegaly (CA; n=17). Metabolic, anthropometric and laboratory values of subjects were recorded. FGF-21 level was measured by ELISA assay.Results Median FGF-21 levels were significantly higher in acromegaly group compared to control group (85.5 vs. 59.0pg/mL, p=0.02, respectively). In the multiple regression model, FPG, A1c, HOMA-IR, glucose intolerance, BMI, visceral fat, hs-CRP, presence of hypertension, dyslipidemia and acromegaly were included as independent variables to explain variability of plasma FGF-21 levels in whole study group. The presence of acromegaly was the only determinant of increased FGF-21 levels in the whole study group ( coefficient=0.253, p=0.006).Conclusion FGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly. Acromegaly may also be a FGF-21 resistance state independent from insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemia.Öğe Alterations of gastric and esophageal functions in obese cases(Springer, 2009) Omur, O.; Erdogan, M.; Mutlukoca, N.; Saygili, F.; Ozkilic, H.; Yilmaz, C.Öğe Alterations of gastric and esophageal functions in obese cases(Springer, 2009) Omur, O.; Erdogan, M.; Mutlukoca, N.; Saygili, F.; Ozkilic, H.; Yilmaz, C.Öğe AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells(Springer, 2018) Yurekli, B. S.; Karaca, B.; Kisim, A.; Bozkurt, E.; Atmaca, H.; Cetinkalp, S.; Ozgen, G.; Yilmaz, C.; Uzunoglu, S.; Uslu, R.; Saygili, F.Purpose Gossypol, a naturally occurring compound in cottonseeds, has anticancer effects against several tumor cell lines. It has been extensively studied in clinical trials and is well tolerated with a favorable safety profile. AT-101, a derivative of R (-)-gossypol, binds to Bcl-2 family proteins and induces apoptosis in vitro. Although transsphenoidal surgical excision of the pituitary corticotroph adenoma is the gold standard of care, it is not successful all the time. Medical therapy for Cushing's disease still remains a challenge for the clinicians. We aimed to investigate the cytotoxic and apoptotic effects of AT-101 in mouse pituitary corticotroph tumor AtT20 cells. Methods Cytotoxic effect of AT-101 was assessed by XTT cell viability assay. Apoptosis was shown by measuring DNA fragmentation and Caspase-3/7 activity. Changes in mRNA expressions of apoptosis-related genes were investigated by qPCR array after treatment with AT-101. ACTH was measured by ACTH-EIA Kit. Results AT-101 induced cytotoxicity and apoptosis in AtT20 cells. mRNA levels of pro-apoptotic genes such as TNFR-SF-10B, Bid, PYCARD, Caspase-8, Caspase-3, and Caspase-7 were induced by 2.0-, 1.5-, 1.7-, 1.5-, 1.6-, and 2-fold, respectively, in AtT20 cells by AT-101 treatment. Moreover, some of the anti-apoptotic genes such as BCL2L10, NAIP1, and PAK-7 were reduced by 2.1-, 2.3-, 4.0-fold, respectively, in AtT20 cells. AT-101 also decreased ACTH secretion significantly. Conclusion AT-101 induces apoptosis in mouse pituitary corticotroph tumor cells.Öğe Causes of high bone alkaline phosphatase(Diagnosis Press Ltd, 2007) Sarac, F.; Saygili, F.Serum alkaline phosphatase (ALP) is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. Many things may cause increases of ALP activity in serum, the most common being obstructive liver disease and metabolic bone disease. An increase of the liver or particularly the bone isoform (bone specfic ALP) in serum can provide valuable diagnostic information. Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia. The enzyme activity, which is localized in the plasma membrane of osteoblasts before extracellular release, correlates with the extent of the disease on skeletal surveys and with parameters of bone resorption. This isoenzymes is normally elevated in growing children and adults over the age of fifty. Causes of high bone ALP include bone growth, healing fracture, acromegaly, osteogenic sarcoma, or bone metastases, leukemia, myelofibrosis, and rarely myeloma; so ALP is used as a tumor marker. Hyperthyroidism, by its effects upon bone, may also elevate ALP We presented two patients have raised alkaline phosphatase. Isoenzyme studies confirmed its bony origin.Öğe Changes in the lipid levels during the mobilization processes(Nature Publishing Group, 2015) Ozkan, M. Comert; Yavasoglu, I.; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Changes in the lipid levels during the mobilization processes(Nature Publishing Group, 2015) Ozkan, M. Comert; Yavasoglu, I.; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Changes in the lipid levels during the mobilization processes(Nature Publishing Group, 2015) Ozkan, M. Comert; Yavasoglu, I.; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Demographic and clinical features of patients with subacute thyroiditis: Results of 169 patients from a single University Center in Turkey(Springer, 2007) Erdem, N.; Erdogan, M.; Ozbek, M.; Karadeniz, M.; Cetinkalp, S.; Ozgen, A. Gokhan; Saygili, F.; Yilmaz, C.; Tuzun, M.; Kabalak, T.Background: Turkey is an endemic area for thyroid diseases. The Aegean region is well documented for increased prevalence of thyroid disorders. In this study we investigated the demographic and clinical features of subacute thyroiditis (SAT) patients who had been diagnosed and treated in Ege University. Methods: The hospital files of patients admitted to the endocrinology clinic of Ege University between January 1987 and December 2001 were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Results: 176 fulfilled diagnostic criteria for SAT. The majority of patients with SAT were diagnosed as having subacute granulomatous thyroiditis (169/176) (134 females, 35 males, mean age 34.0 +/- 17.8 yr); 69% of the patients were between 30-50 yr of age. Thyroid pain was present in 97.1% of female patients, and in 100% of male patients. High fever was evident in 78 patients (46.2%). Mean erythrocyte sedimentation rate (ESR) was 43-42 +/- 39.68 mm/h. Anti-thyroglobulin antibody was positive in 20%, and anti-thyroid per-oxydase antibody was positive in 4% of patients. Among patients who were treated with non-steroidal anti-inflammatory drugs (NSAD) 10 female patients (10.6%), and 3 male patients (12%) developed recurrence of the disease. Among patients who were treated with prednisolone 7 female patients (17.5%), and one male patient (10%) developed recurrence. There was no significant difference regarding the recurrence rates between patients who were treated with NSAD and patients who were treated with prednisolone. Conclusion: With the exception of ESR, demographic, clinical, laboratory, and imaging findings and prognoses of our patients were comparable to the previous reports.Öğe Effect of hypercholesterolaemia on peripheral blood CD34+cell levels(Nature Publishing Group, 2015) Ozkan, M. Comert; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Yavasoglu, I.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Effect of hypercholesterolaemia on peripheral blood CD34+cell levels(Nature Publishing Group, 2015) Ozkan, M. Comert; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Yavasoglu, I.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Effect of hypercholesterolaemia on peripheral blood CD34+cell levels(Nature Publishing Group, 2015) Ozkan, M. Comert; Simsir, I. Yildirim; Yurekli, B. Sarer; Basol, G.; Yavasoglu, I.; Kabaroglu, C.; Saygili, F.; Bolaman, Z.; Tombuloglu, M.; Donmez, A.Öğe Effects of sibutramine on thermogenesis in obese patients assessed via immersion calorimetry(Health Communications Inc, 2006) Sarac, F.; Pehlivan, M.; Celebi, G.; Saygili, F.; Yilmaz, C.; Kabalak, I.Glucose utilization studies show that sibutramine-induced thermogenesis is mediated via selective sympathetic activation of brown adipose tissue. The goal of the present study was to use a new calorimetry method in which resting metabolic rate is enhanced to evaluate the effects of sibutramine treatment on thermogenesis. Sixty obese women were included in the study. Subjects were divided into 2 equal groups-the placebo and sibutramine treatment groups. The sibutramine group was given sibutramine 10 mg daily for 12 wk. At baseline and at the end of the 12-wk treatment period, thermogenic measurements were taken with the use of water immersion calorimetry. Subjects were examined at weeks 4, 8, and 12 of treatment to identify adverse effects. Body mass index, measured at 31.5 +/- 2.05 kg/m(2) in the placebo group, decreased to 30.4 +/- 2.94 kg/m(2) after 12 wk (P=.07). In the sibutramine group, it decreased from 33.5 +/- 4.1 kg/m(2) to 30.9 +/- 4.8 kg/m(2) (P <.05). In the sibutramine group, mean thermogenic response changed from a baseline value of 1.27 +/- 0.29 kcal/kg/h to 1.44 +/- 0.13 kcal/kg/h after 12 wk of treatment. In the placebo group, the baseline value was 1.56 +/- 0.27 kcal/kg/h; it changed to 1.33 +/- 0.36 kcal/kg/h at the end of 12 wk. The findings of this study suggest that sibutramine treatment promotes thermogenesis, thus facilitating weight loss. Calorimetry enhances resting metabolism through more efficient heat transfer from the body.Öğe Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2009) Ozbek, M.; Erdogan, M.; Karadeniz, M.; Cetinkalp, S.; Ozgen, A. G.; Saygili, F.; Yilmaz, C.; Tuzun, M.Background and aims: Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients. Materials and methods: Twenty-four newly diagnosed type 2 diabetic patients were enrolled in this study. All patients were ingested a mixed meal of 553 kcal. Serum insulin levels were measured at time 0 just before the mixed meal and at 1, 2, 3, 4 and 5 h after the ingestion of the mixed meal. Twenty-four hours later, all patients ingested mixed meal followed by oral 8g L-Arginine, and insulin levels were again measured at 0, 1, 2, 3, 4 and 5 h after the ingestion of the meal. Results: Insulin levels reached to peak values at the 2(nd) hour, and decreased to baseline levels at the 5(th) hour measurements both after the ingestion of mixed meal only and after the ingestion of mixed meal plus oral L-Arginine. First and 2(nd) hour insulin levels were significantly higher after the ingestion of mixed meal plus oral L-Arginine. Conclusion: In this study we used for the first time the combination of oral L-arginine with mixed meal test to evaluate the beta cell dysfunction in type 2 diabetic patients. Increments regarding serum insulin levels after the ingestion of mixed meal plus oral L-Arginine suggest that oral L-Arginine could be benefical for the evaluation of beta cell function and secretory defects.Öğe Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes Mellitus(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2009) Ozbek, M.; Erdogan, M.; Karadeniz, M.; Cetinkalp, S.; Ozgen, A. G.; Saygili, F.; Yilmaz, C.; Tuzun, M.Background and aims: Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients. Materials and methods: Twenty-four newly diagnosed type 2 diabetic patients were enrolled in this study. All patients were ingested a mixed meal of 553 kcal. Serum insulin levels were measured at time 0 just before the mixed meal and at 1, 2, 3, 4 and 5 h after the ingestion of the mixed meal. Twenty-four hours later, all patients ingested mixed meal followed by oral 8g L-Arginine, and insulin levels were again measured at 0, 1, 2, 3, 4 and 5 h after the ingestion of the meal. Results: Insulin levels reached to peak values at the 2(nd) hour, and decreased to baseline levels at the 5(th) hour measurements both after the ingestion of mixed meal only and after the ingestion of mixed meal plus oral L-Arginine. First and 2(nd) hour insulin levels were significantly higher after the ingestion of mixed meal plus oral L-Arginine. Conclusion: In this study we used for the first time the combination of oral L-arginine with mixed meal test to evaluate the beta cell dysfunction in type 2 diabetic patients. Increments regarding serum insulin levels after the ingestion of mixed meal plus oral L-Arginine suggest that oral L-Arginine could be benefical for the evaluation of beta cell function and secretory defects.Öğe GLUCOSE TOLERANCE TESTS IN THE SINGLETON AND TWIN PREGNANCY(Editura Acad Romane, 2009) Sarac, F.; Tutuncuoglu, P.; Tavmergen, E.; Saygili, F.; Ozgen, A. Goekhan; Tuzun, M.Objective. Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is detected for the first time during pregnancy. Normal pregnancy induces insulin resistance through the diabetogenic effects of placental hormones. Glucose tolerance test results in twin and singleton pregnancies were compared in this study. Subjects and Methods. A total of 360 pregnant women were Studied. 200 women (mean age 31.60 +/- 2.10 yr) had singleton pregnancies (Group I) and 160 women (mean age 28.20 2.70 yr) had twin pregnancies (Group II). 50- g, 1- hour glucose tolerance test was conducted oil the first prenatal visit. An abnormal glucose screen defined as glucose >= 140 mg/dL was followed by a 100g, 3-hour glucose tolerance test. Gestational diabetes was defined as the presence of two or more abnormal values during the 3-hour test. Results. Gestational diabetes was found in 4 of the 200 (2%) singleton pregnant women and 8 of the 160 (5%) twin pregnant women. Group I (Singleton) was further divided into two Subgroups according to whether the 1-hr plasma glucose level was < 140 mg/dl (Group Ia) or > 140 ma/dL (Group Ib). Likewise, Group II pregnancies was also divided into two subgroups oil the same basis. Mean screening test glucose levels were found to be 127.8 +/- 14.94 mg/dL ill Group la and 150.8 +/- 18.1 mg/dL in Group Ib women. Mean screening test glucose levels of Group IIa subjects was 92.80 +/- 18.30 mg/dL while that of Group IIb Subjects was 154.8 +/- 27.0 mg/dL. Mean 1(st) h glucose levels of 100-g glucose tolerance test was found to be 131.4 +/- 32.58 mg/dL in Group I, and 112.5 +/- 39.6 mg/dL in Group II. Mean 2(nd) h glucose tolerance test values were 133.2 +/- 28.8 mg/dL in Group I and 100.6 +/- 28.8 mg/dL in Group II. Mean 3(rd) h glucose tolerance test values were 107.6 +/- 23.58 mg/dl in Group I and 72 +/- 16.9 mg/dL in Group II. Conclusion: Glucose screening results and 100-g, 3- hour glucose tolerance test values have been found to be lower in twin pregnancies than in singleton pregnancies. Therefore, we suggest that these findings be taken into account in developing diagnostic criteria for gestational diabetes ill twin or more pregnancies.Öğe The importance of anti-insulin antibody in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion or multiple daily insulin injections therapy(Springer-Verlag Italia Srl, 2010) Sahin, S. B.; Cetinkalp, S.; Ozgen, A. G.; Saygili, F.; Yilmaz, C.To investigate the influence of two insulin administration modalities, continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) therapy with insulin analogues, on the development of insulin antibodies (IAs) in patients with type 1 diabetes mellitus and to assess the impact of IAs on glucose control and hypoglycaemia. 96 patients with type 1 diabetes mellitus treated with CSII (n = 48) or MDI (n = 48) were included in the study. Age, duration of diabetes, A1c, preprandial and postprandial blood glucose and hypoglycaemic events were compared between IA positive and negative patients. IA levels were higher in the CSII group (% 24.6 +/- A 14.2) than the MDI group (% 13.2 +/- A 9.9). Duration of diabetes and age were not associated with IA positiveness. While A1c, preprandial blood glucose and the frequency of hypoglycaemic events were similar in two groups, postprandial blood glucose was lower in IA positive group (P = 0.03). Patients with type 1 diabetes mellitus treated with CSII with insulin analogues had higher IA levels when compared to MDI therapy. However, the development of IAs did not impair the glycaemic control.Öğe Pituitary apoplexy in an adrenocorticotropin-producing pituitary macroadenoma(Humana Press Inc, 2010) Sahin, Serap Baydur; Cetinkalp, S.; Erdogan, M.; Cavdar, U.; Duygulu, G.; Saygili, F.; Yilmaz, C.; Ozgen, A. G.Adrenocorticotropin (ACTH) producing macroadenomas and pituitary apoplexy are unusual in Cushing's disease. A 20-year-old man who had been diagnosed Cushing's disease 2 months ago, presented with sudden headache, nausea, and vomiting. His serum cortisol level was 0.4 mu g/dl and ACTH level was 23.9 pg/ml. Magnetic resonance imaging of the pituitary gland disclosed a hemorrhage in the pituitary macroadenoma (22 x 19 mm). He was treated with IV methylprednisolone immediately and then the symptoms were relieved within the first day of the treatment. The hemorrhagic lesion was resected by transsphenoidal surgery successfully. Impaired secretion of pituitary hormones may be seen after the pituitary apoplexy. We communicate a case with pituitary apoplexy of an ACTH secreting pituitary macroadenoma, causing acute glucocorticoid insufficiency.Öğe Plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels in diabetic foot ulcers(Humana Press Inc, 2010) Erdogan, M.; Solmaz, S.; Canataroglu, A.; Kulaksizoglu, M.; Cetinkalp, S.; Ozgen, A. G.; Saygili, F.; Yilmaz, C.Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD) and may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of this study was to investigate the association of plasma TAFI antigen level in the development of diabetic foot ulcer in Type 2 diabetes. The TAFI antigen levels were determined in 50 patients with diabetic foot ulcers and 34 patients without diabetic foot ulcers and 25 healthy individuals. We measured TAFIa/ai antigen in plasma samples with a commercially available ELISA Kit. Diabetic foot ulcer group and diabetic group were similar in terms of mean age and sex distribution. Diabetes duration, retinopathy, neuropathy, macrovascular disease and infection were related to diabetic foot ulcers. HbA1c, HDL-cholesterol and Folic Acid levels were decreased in the diabetic foot ulcer group. TAFI levels were 99.44 +/- A 55.94% in control group, 135.21 +/- A 61.05% in diabetic foot ulcer group, 136.75 +/- A 59.38% in diabetic group and was statistically different (P < 0.05). But no difference was seen in TAFI levels between the diabetic foot ulcer group and diabetic group (P > 0.05). No significant difference in plasma TAFI levels were seen between diabetic foot ulcer stages. TAFI antigen levels are increased in Type 2 diabetic patients, but are not related to diabetic foot ulcer development.
