Causes of high bone alkaline phosphatase
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Diagnosis Press Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Serum alkaline phosphatase (ALP) is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. Many things may cause increases of ALP activity in serum, the most common being obstructive liver disease and metabolic bone disease. An increase of the liver or particularly the bone isoform (bone specfic ALP) in serum can provide valuable diagnostic information. Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia. The enzyme activity, which is localized in the plasma membrane of osteoblasts before extracellular release, correlates with the extent of the disease on skeletal surveys and with parameters of bone resorption. This isoenzymes is normally elevated in growing children and adults over the age of fifty. Causes of high bone ALP include bone growth, healing fracture, acromegaly, osteogenic sarcoma, or bone metastases, leukemia, myelofibrosis, and rarely myeloma; so ALP is used as a tumor marker. Hyperthyroidism, by its effects upon bone, may also elevate ALP We presented two patients have raised alkaline phosphatase. Isoenzyme studies confirmed its bony origin.
Açıklama
Anahtar Kelimeler
bone specific alkaline phosphatas, alkaline phosphatase, osteomalacia, paget's disease
Kaynak
Biotechnology & Biotechnological Equipment
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
21
Sayı
2
