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Öğe Cervical dysplasia after renal transplantation: A retrospective cohort study(Galenos Yayincilik, 2021) Bilgi, Ahmet; Gokulu, Sevki Goksun; Ilgen, Orkun; Kulhan, Mehmet; Kavurmaci, Seda Akgun; Toz, Huseyin; Terek, Mustafa CosanObjective: Since the first days of organ transplantation, it has been accepted that solid transplant recipients have a high risk of developing cancer. Chronic immunosuppression and environmental factors play a role in cancer development in recipients. in the present study, we tried to evaluate the cumulative incidence of cervical dysplasia after renal transplantation, risk factors for disease development, and the time until high-grade dysplasia occurred. Materials and Methods: A total of 50 patients with renal transplantation who presented for gynecologic follow-up was included in the study. The medical records of the patients were reviewed until the last clinical visit, their demographic characteristics, transplant history, gynecologic history, and gynecologic examination results (cervical cytology and histology reports) were reviewed. Results: of the 50 women in the study population, 29 (58%; 95% confidence interval: 8.8-15.9) developed cervical dysplasia after the first transplant at a median follow-up of 7.8 (range: 4.6-12.9) years. Twenty-one women with benign cervical cytology before transplantation had evidence of low-grade intraepithelial lesions + after transplant (47% of these were within 2 years after transplant). During the follow-up, 8 women (18.2%) were diagnosed as having high-grade intraepithelial lesions + (within 5 years after transplantation). Conclusion: Renal transplant patients were found to have higher abnormal cervical cytology and histology rates than the normal population.Öğe Comparison of laparoscopic and open surgery in obese patients with endometrial cancer(2022) Özsaran, Ahmet Aydın; Akman, Levent; Sancar, Ceren; Terek, Mustafa Coşan; Yıldırım, Nuri; Bilgi, Ahmet; Gökülü, SevkiAim: The aim of the study is to compare the results of total laparoscopic hysterectomy and total abdominal hysterectomy in obese women with endometrial cancer (EC). Materials and Methods: Patients with endometrial cancer whose BMI ?30 kg/m2 and who were undergone total laparoscopic hysterectomy (n=68) or total abdominal hysterectomy (n=161) were included in the study. Demographic and histopathological features, disease-free survival and overall survival of the patients were recorded. All these data of laparoscopy and laparotomy patients were compared with each other. Results: No significant difference was observed between two groups in terms of stage, tumor grade, histology, lymph node dissection rate and number of removed lymph nodes. Cardiovascular diseases were more common in laparotomy group (p=0.002). ASA (American Society of Anesthesiologists) score was higher in laparotomy group (p=0.001). Perioperative and postoperative complications were similar in both groups. The operation time was significantly longer and postoperative hospital stay was significantly shorter in the laparoscopy group (p<0.0001). There was no significant difference between two groups in disease-free survival and overall survival. The overall survival rate was 90.7% in the laparoscopy group and 95.1% in the laparotomy group (p = 0.789). Conclusion: Our results showed that in obese patients with EC, laparoscopy had similar oncological outcomes with laparotomy and was also more beneficial for patients in terms of a shorter hospital stay.Öğe The effect of resistance exercise on quality of life and fatigue in patients with gynecological cancer(2022) Şenışık, Seçkin; Yörük, İhsan; Bilgi, AhmetObjective: It is known that the quality of life decreases and fatigue increases in cancer patients due to the disease and the effects of treatment. Regular exercise can significantly improve these complaints. The aim of this study is to investigate the effect of resistance exercises on quality of life and fatigue in patients with gynecological cancer. Materials and Methods: Patients who completed gynecological cancer treatment were randomized to form the exercise group (n=80) and the control group (n=80). Quality of life and cancer-related fatigue were determined by means of Functional Assessment of Cancer Therapy-General and Functional Assessment of Chronic Illness Therapy-Fatigue, in order, as primary outcome measurements. Body mass index (BMI), body fat ratio, hand grip strength, hip and back extensor group muscle strength were determined as secondary outcome measurements. Results: At the end of the study, significant improvements were observed in the quality of life (p<0.001) and fatigue (p<0.001), as well as body composition and strength values (p<0.001) in the exercise group compared to the control group. The levels of change in the values were more significant in the exercise group (p<0.001). A significant correlation was found between the changes in physical parameters (body fat ratio, BMI) and the changes in quality of life and fatigue levels (p<0.001). Conclusions: It was revealed that resistance exercises could significantly reduce cancer-related fatigue and improve quality of life in patients with gynecological cancer. It can be concluded that resistance exercises can contribute to the treatment process and the patient’s quality of life.Öğe The Impact of Surgical Staging on the Prognosis of Mucinous Borderline Tumors of the Ovaries: A Multicenter Study(Int Inst Anticancer Research, 2017) Gungorduk, Kemal; Asicioglu, Osman; Braicu, Elena Ioana; Almuheimid, Jumana; Gokulu, Sevki Goksun; Cetinkaya, Nilufer; Gungor, Tayfun; Pakay, Gonca; Telli, Elcin Uzmez; Cuylan, Zeliha Firat; Toptas, Tayfun; Bilgi, Ahmet; Ozyurt, Ramazan; Agacayak, Elif; Ozdemir, Aykut; Yildirim, Nuri; Taskin, Salih; Oge, Tufan; Erol, Onur; Akman, Levent; Turan, Anil; Icen, Mehmet Sait; Senol, Taylan; Ovali, Ozlem Irak; Yucesoy, Burcu; Gungorduk, Ozgu; Temizkan, Osman; Sanci, Muzaffer; Simsek, Tayup; Meydanli, Mehmet Mutlu; Harma, Mehmet; Yasar, Levent; Uysal, Aysel Derbent; Karateke, Ates; Ortac, Firat; Ozalp, Sabit Sinan; Sehouli, Jalid; Muallem, Mustafa ZelalBackground/Aim: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). Patients and Methods: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT. Results: A total of 364 patients with mBOT with a median age of 43.1 years were included in this analysis. The median OS of all patients was 53.1 months. The majority of cases had Stage IA (78.6%). In univariate and multivariate analyses, radical surgery, omentectomy, appendectomy, lymphadenectomy, and adding adjuvant chemotherapy were not independent prognostic factors for PFS and OS. Furthermore, FIGO stage (>= IC vs. = IC vs.Öğe In Vitro Determination of Wound. Healing Potential of Axonge(H M P Communications, 2017) Bilgi, Ahmet; Muftuler, Fazilet Zumrut Biber; Akman, Levent; Medine, Emin Ilker; Bilgi, Pinar Tonbaklar; Guldu, Ozge Kozgus; Gokulu, Sevki Goksun; Tekin, Volkan; Terek, Mustafa CosanBackground. Research on treatment alternatives that improve wound healing is an ever-evolving area in medicine, and a wound healing agent that carries minimal pain, discomfort, and scarring for patients with burn wounds, venous and decubitis ulcers, traumatic wounds, and many others is needed. The phases of wound healing include homeostasis, inflammation, migration, proliferation, and maturation. Adeps suillus (axonge) is known as a therapeutic agent for skin diseases and mainly consists of triglycerides. Objective. In the current study, the proliferation effect of axonge was determined on human normal epidermal keratinocyte (HaCaT) cells and human normal foreskin fibroblast cell line (BJ) cells. Materials and Methods. Experimental steps included preparation of HaCaT and BJ cell lines, axonge's stable tetrazolium salt-based proliferation assay, and evaluation of the wound healing effect of axonge on HaCaT and BJ cells. Results. Axonge concentrations of 3.12 mu g/mL, 6.25 mu g/mL, 12.5 mu g/mL, 25 mu g/mL, and 50 mu g/mL showed no cytotoxic effect on both HaCaT and BJ cells for 24, 48, and 72 hours. Considering the wound area of HaCaT cells, after 6 hours the wound healing effect of the axonge group reached almost 70% and then stopped. According to the results of the study on. BJ cells, after 6 hours axonge wound closure was found to be 50% while the control group was only 10%. Conclusion. On the basis of this study, the authors determined that axonge might have potential for use in wound healing.Öğe Investigation of nanoformulation and incorporation potential of radiolabeled curcumin using HeLa and MDAH-2774 cells(Springer, 2021) Gokulu, Sevki Goksun; Kilcar, Ayfer Yurt; Bilgi, Ahmet; Karatay, Kadriye Busra; Yildirim, Nuri; Kayas, Cansu; Terek, Mustafa CosanNowadays plant origin compounds with anti-cancer properties come into prominence, among them is curcumin (CUR) with a remarkable anti-cancer activity against various cancers. CUR was nanoformulated (CUR-PLGA) by the polymer based poly(lactic-co-glycolic acid) (PLGA) and both CUR and CUR-PLGA were radiolabeled with iodine-131 radionuclide for investigation of their in vitro behaviour on Human cervix adenocarcinoma (HeLa) and Ovarian endometrioid adenocarcinoma (MDAH-2774) cell lines. The newly described radiolabeled CUR and CUR-PLGA may be initiative discovery of novel potential imaging and therapeutic agents.Öğe mTOR inhibitors from a diagnostic perspective: radiolabeling of everolimus and its nanoformulation, in vitro incorporation assays against cervix and ovarian cancer cells(Springer, 2022) Bilgi, Ahmet; Kilcar, Ayfer Yurt; Gokulu, Sevki Goksun; Kayas, Cansu; Yildirim, Nuri; Karatay, Kadriye Busra; Akman, LeventmTOR inhibitors are recently important tools for cancer treatment. They act on cell growth regulation, proliferation, and survival. Pharmacological therapy with mTOR inhibitors such as everolimus is emerging as an alternate approach. Meanwhile, early diagnosis is a hot target in cancer research. Conversely, it can be a novel diagnosis approach to monitor mTOR inhibitors during their pathway. From this point of view, radiolabeling of everolimus and its nanoformulation (EVE-PLGA nanoparticles) in high yields (95%) with an important diagnostic radionuclide (technetium-99m) is described. Besides, in vitro incorporation assays of radiolabeled everolimus and its nanoformulation against the cervix and ovarian cancer cells were demonstrated 8- and 12-times high values than control group. In conclusion, radiolabeled everolimus and its nanoformulation have a promise to improve on monitoring mTOR inhibitors.Öğe The relationship of menstrual irregularity with AMH, ghrelin and leptin levels in athletes(2021) Şenışık, Seçkin; Bilgi, Ahmet; Köyağasıoğlu, Ogün; Bilgi, Pınar; Güldü, Özge Kozguş; Yılmaz, Bulent; Terek, Mustafa CoşanObjective: To explore menstrual irregularity rates in female professional basketball and volleyball players and investigate the relationship with Anti-Müllerian Hormone (AMH), ghrelin, leptin levels and biochemical parameters. Material and Methods: Forty-one professional female athletes and forty-one non-athlete controls aged 18-35 years participated in the study. Questioning of menstrual function has been performed and whole blood counts, AMH, leptin, ghrelin and other endocrine and metabolic parameters were evaluated. Results: 41% of female athletes and in 24% of non-athlete controls revealed menstrual irregularities. AMH, ghrelin, leptin levels were similar in athletes and control group (p>0.05). While athletes with menstrual irregularities tend to have lower ghrelin and leptin levels and higher AMH than athletes without irregularities, the difference was not statistically significant (p>0.05). No significant difference was found between the groups in terms of endocrine and other metabolic parameters (p>0.05). There was a significant negative correlation between ghrelin and menstrual irregularity (r=-0.240, p=0.031) and a statistically significant positive correlation between AMH and testosterone levels (r=-0.247, p=0.025). There was no significant relationship between other parameters (p>0.05).Öğe Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation(Springer, 2024) Gokulu, Sevki Goksun; Karatay, Kadriye Busra; Bilgi, Ahmet; Kayas, Cansu; Yildirim, Nuri; Kilcar, Ayfer Yurt; Muftuler, Fazilet Zumrut BiberLapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(Tc-99m) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [Tc-99m]Tc-LPT and [Tc-99m]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer.Öğe Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells(Springer, 2016) Akman, Levent; Muftuler, Fazilet Zumrut Biber; Bilgi, Ahmet; Kilcar, Ayfer Yurt; Gokulu, Sevki Goksun; Medine, Emin Ilker; Terek, Mustafa CosanThe aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (I-131) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.
