Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Lapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(Tc-99m) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [Tc-99m]Tc-LPT and [Tc-99m]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer.
Açıklama
Anahtar Kelimeler
Poly(Lactic-Co-Glycolic Acid) (Plga), Lapatinib (Lpt), Technetium-99 M (Tc-99m), Human Breast Adenocarcinoma (Mda-Mb-231), Cervix Adenocarcinoma (Hela), Human Ovarian (Mdah-2774)
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
333
Sayı
2
