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Öğe The effects of hydroxyethyl starch and succinylated gelatin on coagulation [% 6 hidroksietil nişasta (130/0.4) ve % 4 süksinilli jelâtin solüsyonlari{dotless}ni{dotless}n koagülasyona etkileri](2009) Ulukaya S.; Alper I.; Balcioglu S.T.Aim: In this study, the effects of 6 % hydroxyethyl starch (HES) 130/0.4) and 4 % succinylated gelatin solutions on coagulation were evaluated in blood samples of patients with normocoagulation based on thrombelastogram data in an in-vitro study design. Material and Methods: Blood samples were diluted with both colloids in 0 %, 20 %, 30 % and 40 % hemodilutions and analysed with a thrombelastograph. Results: With both solutions in these hemodilutions, the time to onset of coagulation /reaction times) was not affected. However, as hemodilution levels increased, the clot propagation rates (coagulation-k time and alpha-angle) and maximum clot strength (maximum amplitude-MA) decreased statistically significantly in the HES group, when compared to the gelatin group (p<0.05). Conclusion: The results of this in-vitro designed study performed with net hemodilution rates indicate that 6 % HES (130/0.4) solution seems to be advantageous in patients having dangerous clinical hypercoagulopathy where tendency to coagulation should be alleviated, while 4 % succinylated gelatin seems to be advantageous in patients having decreased coagulation status. However we think that these data should be supported by further research carried out in an in-vivo design including a larger population.Öğe Morquio syndrome and anaesthesia (Case report)(1992) Balcioglu S.T.; Aksu H.; Ovul F.; Tutan A.[No abstract available]Öğe The pharmacodynamic effects of rocuronium in morbidly obese patients [Morbid Obez Hastalarda Rokuronyumun Farmakodinamik Etkileri](2009) Ankan N.; Alper I.; Ulukaya S.; Balcioglu S.T.; Yegül I.Aim: In this study, we aimed to investigate the pharmacodynamic effects of rocuronium when dosed according to real or ideal body weights of morbidly obese patients and compare the results with normal body weight patients. Material and Methods: Sixteen morbidly obese patients (body mass index [BMI] >40 kg/m- 2) and 8 patients with normal body weights (BMI <30 kg/m- 2, control group) were given rocuronium (0.6 mg/kg iv) during application of anaesthesia The dose of rocuronium was based on the real (RBW, n=8) or ideal body weights (IBW, n=8) in morbidly obese patients. The neuromuscular blockade properties of three groups were compared. Results: The median onset time of rocuronium in the IBW group was significantly longer than that in the RBW and control group (210 versus 80 and 105 sec, respectively; p<0.05), while the duration of action was significantly shorter (28 versus 66 and 42 min, p<0.05). Any statistically significant difference in the recovery index were found between the groups (3.5 vs 4.5 and 2.5 min, p>0.05). Conclusion: Dosing rocuronium according to the ideal body weights in morbidly obese patients resulted in delayed onset time and shorter clinical duration when compared to the patients with normal body weights or morbidly obese patients who received rocuronium based on their real body weights. In addition to the type and duration of the operation, individually adjusted dosing may be required in morbidly obese patients when more rapid induction is necessary.Öğe Venous air embolism during orthotopic liver transplantation in a pediatric patient [Pediyatrik ortotopik karaciger transplantasyonu sirasinda gelişen venöz hava embolisi](2008) Alper I.; Ulukaya S.; Küpeli U.; Balcioglu S.T.; Kilic M.In this case report, the diagnosis and treatment of venous air embolism requiring vasoconstrictor drug treatment together with cardiac compressions and rapid volume replacement during dissection period of living donor liver transplantation in a pediatric case is discussed.
