The effects of hydroxyethyl starch and succinylated gelatin on coagulation [% 6 hidroksietil nişasta (130/0.4) ve % 4 süksinilli jelâtin solüsyonlari{dotless}ni{dotless}n koagülasyona etkileri]
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: In this study, the effects of 6 % hydroxyethyl starch (HES) 130/0.4) and 4 % succinylated gelatin solutions on coagulation were evaluated in blood samples of patients with normocoagulation based on thrombelastogram data in an in-vitro study design. Material and Methods: Blood samples were diluted with both colloids in 0 %, 20 %, 30 % and 40 % hemodilutions and analysed with a thrombelastograph. Results: With both solutions in these hemodilutions, the time to onset of coagulation /reaction times) was not affected. However, as hemodilution levels increased, the clot propagation rates (coagulation-k time and alpha-angle) and maximum clot strength (maximum amplitude-MA) decreased statistically significantly in the HES group, when compared to the gelatin group (p<0.05). Conclusion: The results of this in-vitro designed study performed with net hemodilution rates indicate that 6 % HES (130/0.4) solution seems to be advantageous in patients having dangerous clinical hypercoagulopathy where tendency to coagulation should be alleviated, while 4 % succinylated gelatin seems to be advantageous in patients having decreased coagulation status. However we think that these data should be supported by further research carried out in an in-vivo design including a larger population.
Açıklama
Anahtar Kelimeler
Coagulation, Gelatin, Hydroxyethyl starch, Thrombelastogram
Kaynak
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
37
Sayı
5
