The pharmacodynamic effects of rocuronium in morbidly obese patients [Morbid Obez Hastalarda Rokuronyumun Farmakodinamik Etkileri]
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: In this study, we aimed to investigate the pharmacodynamic effects of rocuronium when dosed according to real or ideal body weights of morbidly obese patients and compare the results with normal body weight patients. Material and Methods: Sixteen morbidly obese patients (body mass index [BMI] >40 kg/m- 2) and 8 patients with normal body weights (BMI <30 kg/m- 2, control group) were given rocuronium (0.6 mg/kg iv) during application of anaesthesia The dose of rocuronium was based on the real (RBW, n=8) or ideal body weights (IBW, n=8) in morbidly obese patients. The neuromuscular blockade properties of three groups were compared. Results: The median onset time of rocuronium in the IBW group was significantly longer than that in the RBW and control group (210 versus 80 and 105 sec, respectively; p<0.05), while the duration of action was significantly shorter (28 versus 66 and 42 min, p<0.05). Any statistically significant difference in the recovery index were found between the groups (3.5 vs 4.5 and 2.5 min, p>0.05). Conclusion: Dosing rocuronium according to the ideal body weights in morbidly obese patients resulted in delayed onset time and shorter clinical duration when compared to the patients with normal body weights or morbidly obese patients who received rocuronium based on their real body weights. In addition to the type and duration of the operation, individually adjusted dosing may be required in morbidly obese patients when more rapid induction is necessary.
Açıklama
Anahtar Kelimeler
Morbid obesity, Neuromuscular monitoring, Rocuronium
Kaynak
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
37
Sayı
4
