Yazar "Aydogan, Cansu" seçeneğine göre listele

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    A Functional Platform for the Detection of JWH-073 as a Model for Synthetic Cannabinoids
    (Wiley-V C H Verlag Gmbh, 2018) Sengel, Tulay Yilmaz; Celik, Emine Guler; Aydogan, Cansu; Gumus, Zinar Pinar; Ilktac, Raif; Aydindogan, Eda; Ciftci, Mustafa; Aldemir, Ebru; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf
    During the last decade, progress has been made in the on-site detection of abused drug use. Herein, we present an electrochemical biosensor for the detection of one of the synthetic cannabinoids (SCs), JWH-073, using poly (methyl methacrylate) (PMMA) hyperbranched copolymer (HBC) as a base coating and antibody molecules to bind the JWH-073 to the surface. Modification of the surface is proved with various techniques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectrometry. The limit of detection and linearity (in logarithmic scale) for JWH-073 were found to be 31.87 ng/mL and 25-500 ng/mL, respectively. The selectivity of the proposed biosensor was also tested in the presence of interfering molecules and the response was much higher for JWH-073 in all measurements. In the final part of the study, synthetic urine was tested with the device and the relative standard deviation value was calculated to be less than 5.0%. The confirmation of data from the resulting bio-platform was performed via LC-QTOF/MS. This work is the first of its kind, a novel, rapid, cost-effective sensing platform for the detection of the SC.
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    Functional Surfaces Constructed with Hyperbranched Copolymers as Optical Imaging and Electrochemical Cell Sensing Platforms
    (Wiley-V C H Verlag Gmbh, 2018) Balta, Sebila; Aydogan, Cansu; Demir, Bilal; Geyik, Caner; Ciftci, Mustafa; Guler, Emine; Demirkol, Dilek Odaci; Timur, Suna; Yagci, Yusuf
    In the present study, hyperbranched copolymers (HBCs), namely poly(methyl methacrylate) (PMMA)-co-poly(2-hydroxyethylmethacrylate) and PMMA-co-poly(2-dimethylamino ethyl methacrylate), are photochemically synthesized by self-condensing vinyl polymerization of methyl methacrylate with the corresponding inimer using Type II photoinitiators. HBCs with different functional group and branching densities are used as surface coating materials in cellular adhesion and the respective electrochemical-based studies. After the main surface characterization of the synthesized three HBCs with contact angle measurements and atomic force microscopy, HaCaT keratinocytes and human neuroglioblastoma (U-87MG) cell lines to the surfaces are conducted. The adherence of cells is proven by both fluorescence cell imaging and electrochemical methods such as cyclic voltammetry and differential pulse voltammetry. The described strategy involving hyperbranched polymers offers great potential for fabricating various new surfaces in particular on-chip-sensing applications.