Functional Surfaces Constructed with Hyperbranched Copolymers as Optical Imaging and Electrochemical Cell Sensing Platforms
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, hyperbranched copolymers (HBCs), namely poly(methyl methacrylate) (PMMA)-co-poly(2-hydroxyethylmethacrylate) and PMMA-co-poly(2-dimethylamino ethyl methacrylate), are photochemically synthesized by self-condensing vinyl polymerization of methyl methacrylate with the corresponding inimer using Type II photoinitiators. HBCs with different functional group and branching densities are used as surface coating materials in cellular adhesion and the respective electrochemical-based studies. After the main surface characterization of the synthesized three HBCs with contact angle measurements and atomic force microscopy, HaCaT keratinocytes and human neuroglioblastoma (U-87MG) cell lines to the surfaces are conducted. The adherence of cells is proven by both fluorescence cell imaging and electrochemical methods such as cyclic voltammetry and differential pulse voltammetry. The described strategy involving hyperbranched polymers offers great potential for fabricating various new surfaces in particular on-chip-sensing applications.
Açıklama
Anahtar Kelimeler
cell sensing, electrochemical methods, hyperbranched polymers, photopolymerization, self-condensing vinyl polymerization (SCVP)
Kaynak
Macromolecular Chemistry and Physics
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
219
Sayı
2
