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    Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury [Sepsis nedenli akut böbrek hasarında agomelatinin etkilerinin değerlendirilmesi]
    (Turkish Association of Trauma and Emergency Surgery, 2016) Başol N.; Erbaş O.; Çavuşoğlu T.; Meral A.; Ateş U.
    BACKGROUND: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI. METHODS: Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg. RESULTS: In the agomelatine group, reductions were observed in levels of tumor necrosis factor ? (TNF-?), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues. CONCLUSION: Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys. © 2016 TJTES.
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    Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex
    (2009) Uyanikgil Y.; Ateş U.; Baka M.; Biçer S.; Öztaş E.; Ergen G.
    This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex. © 2009 Springer Science+Business Media, LLC.
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    Juvenile neuronal ceroid-lipofuscinosis (Batten disease): A propos an unusual case diagnosed by electron microscopy
    (2004) Ateş U.; Baka M.; Aktug H.; Turgut M.; Tütüncüoglu S.; Yurtseven M.; Öktem G.; Serdaroglu G.
    Neuronal ceroid-lipofuscinosis, Batten disease, is a lysosomal storage disease which clinically and genetically contains heterogenity. Its differential diagnosis is very difficult with clinical and routine laboratory investigations. The authors present a case of juvenile neuronal ceroid lipofuscinosis in an eight-year-old boy. His speech began to regress at the age of 3, but he had characteristic symptoms including myoclonic epileptic seizures, ataxia, spasticity and pyramidal symptoms at the admission. Electron microscopy study of a skin biopsy demonstrated abnormal myelinisation, some degenerative changes in myelin lamellar structure, increased filamentous structure of unmyelinated axons. This case confirms the usefulness of ultrastructural examination of the skin in the diagnosis of this unusual disorder.